SSH3

SSH3
Identifiers
Aliases	SSH3, SSH3L, slingshot protein phosphatase 3
External IDs	OMIM: 606780; MGI: 2683546; HomoloGene: 32372; GeneCards: SSH3; OMA:SSH3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	67,312,607 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,319,208 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; right hemisphere of cerebellum; ; minor salivary glands; ; right uterine tube; ; mucosa of transverse colon; ; vagina; ; skin of leg; ; ectocervix; ; skin of abdomen; ; gastric mucosa;
	Top expressed in
	granulocyte; ; lip; ; esophagus; ; primary visual cortex; ; superior frontal gyrus; ; cerebellar cortex; ; stomach; ; colon; ; neural layer of retina; ; duodenum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; actin binding; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity;
Cellular component	cytoplasm; cytoskeleton; nucleus;
Biological process	regulation of lamellipodium assembly; regulation of axonogenesis; regulation of actin polymerization or depolymerization; protein dephosphorylation; peptidyl-tyrosine dephosphorylation; dephosphorylation; cell morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	54961
	245857
	ENSG00000172830
	ENSMUSG00000034616
	Q8TE77
	Q8K330
	NM_017857; NM_018276
	NM_198113; NM_001356620; NM_001374687
	NP_060327
	NP_932781; NP_001343549
	Wikidata
View/Edit Human	View/Edit Mouse

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Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3 gene.^[5]^[6]

Function

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172830 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034616 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (January 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. S2CID 5576208.
^ ^a ^b "Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)".

Kligys K, Claiborne JN, DeBiase PJ, Hopkinson SB, Wu Y, Mizuno K, Jones JC (November 2007). "The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes". The Journal of Biological Chemistry. 282 (44): 32520–8. doi:10.1074/jbc.M707041200. PMC 2754063. PMID 17848544.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, Sampath R, Bamburg JR, Bernard O (February 2005). "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin". The EMBO Journal. 24 (3): 473–86. doi:10.1038/sj.emboj.7600543. PMC 548651. PMID 15660133.
Ohta Y, Kousaka K, Nagata-Ohashi K, Ohashi K, Muramoto A, Shima Y, Niwa R, Uemura T, Mizuno K (October 2003). "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin". Genes to Cells. 8 (10): 811–24. doi:10.1046/j.1365-2443.2003.00678.x. PMID 14531860. S2CID 24247372.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172830 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034616 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11832213-5] Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (January 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213. S2CID 5576208.

[entrez-6] "Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)".

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Function

References

Further reading