KIF25

KIF25
Identifiers
Aliases	KIF25, KNSL3, kinesin family member 25
External IDs	OMIM: 603815; HomoloGene: 49939; GeneCards: KIF25; OMA:KIF25 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	168,045,091 bp
RNA expression pattern
	Top expressed in
	gonad; ; buccal mucosa cell; ; testicle; ; right hemisphere of cerebellum; ; apex of heart; ; C1 segment; ; abdominal fat; ; right frontal lobe; ; putamen; ; dorsolateral prefrontal cortex;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; microtubule motor activity; nucleotide binding; ATPase activity; ATP binding; minus-end-directed microtubule motor activity;
Cellular component	cytoplasm; microtubule; cytoskeleton; kinesin complex; centrosome; microtubule organizing center;
Biological process	microtubule-based movement; negative regulation of autophagy; organelle organization; mitotic sister chromatid segregation; negative regulation of mitotic centrosome separation; protein homotetramerization; establishment of spindle orientation; nucleus localization;
	Sources:Amigo / QuickGO
Orthologs
	3834
	n/a
	ENSG00000125337
	n/a
	Q9UIL4
	n/a
	NM_005355; NM_030615
	n/a
	NP_005346; NP_085118
	n/a
	Wikidata
View/Edit Human

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Kinesin family member 25 (KIF25), also known as kinesin-14, is a human protein encoded by the KIF25 gene. It is part of the kinesin family of motor proteins.

Function

KIF25 is a minus-end directed microtubule motor protein, and its activity delays the separation of chromosomes during mitosis.^[3]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125337 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Decarreau J, Wagenbach M, Lynch E, Halpern AR, Vaughan JC, Kollman J, Wordeman L (April 2017). "The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation". Nature Cell Biology. 19 (4): 384–390. doi:10.1038/ncb3486. PMC 5376238. PMID 28263957.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125337 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] Decarreau J, Wagenbach M, Lynch E, Halpern AR, Vaughan JC, Kollman J, Wordeman L (April 2017). "The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation". Nature Cell Biology. 19 (4): 384–390. doi:10.1038/ncb3486. PMC 5376238. PMID 28263957.

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