N-acetiltransferaza 2
| N-acetiltransferaza 2 (arilamin N-acetiltransferaza) | |||||||||||
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| Dostupne strukture | |||||||||||
| 2PFR | |||||||||||
| Identifikatori | |||||||||||
| Simboli | NAT2; AAC2; NAT-2; PNAT | ||||||||||
| Vanjski ID | OMIM: 612182 MGI: 97279 HomoloGene: 115468 GeneCards: NAT2 Gene | ||||||||||
| EC broj | 2.3.1.5 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 10 | 17960 | |||||||||
| Ensembl | ENSG00000156006 | ENSMUSG00000025588 | |||||||||
| UniProt | P11245 | P50294 | |||||||||
| RefSeq (mRNA) | NM_000015 | NM_008673 | |||||||||
| RefSeq (protein) | NP_000006 | NP_032699 | |||||||||
| Lokacija (UCSC) |
Chr 8: 18.25 - 18.26 Mb |
Chr 8: 67.49 - 67.49 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
N-acetiltransferaza 2 (arilamin N-acetiltransferaza), takođe poznata kao NAT2, je enzim koji je kod čoveka kodiran NAT2 genom.[1]
Funkcija
[уреди | уреди извор]Ovaj gen kodira jedan tip N-acetiltransferaza. NAT2 izozim funkcioniše tako što aktivira i deaktivira arilaminske i hidrazinske lekove i karcinogene. Polimorfizam ovog gena je odgovoran za N-acetilacioni polimorfizam kojim se ljudska populacija segregira u brze, srednje i spore acetilatorne fenotipe. Polimorfizmi NAT2 su takođe povezani za povećanom učestalošću kancera i toksičnošću lekova. Drugi arilaminski N-acetiltransferazni gen (NAT1) je lociran blizo NAT2.[2]
Predviđanje fenotipa
[уреди | уреди извор]NAT2 acetilatorni fenotip se može predvideti iz NAT2 genotipa (SNP kombinacije koje data osoba poseduje).[3][4]
Reference
[уреди | уреди извор]- ^ Vatsis KP, Weber WW, Bell DA, Dupret JM, Evans DA, Grant DM, Hein DW, Lin HJ, Meyer UA, Relling MV (1995). „Nomenclature for N-acetyltransferases”. Pharmacogenetics. 5 (1): 1—17. PMID 7773298. doi:10.1097/00008571-199502000-00001.
- ^ „Entrez Gene: NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)”.
- ^ „NAT2PRED: a computational predictor of the human N-AcetylTransferase-2 (NAT2) acetylator phenotype”. State University of New York – Albany. Архивирано из оригинала 22. 05. 2009. г. Приступљено 30. 4. 2009.
- ^ Kuznetsov IB, McDuffie M, Moslehi R (2009). „A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype”. Bioinformatics (Oxford, England). 25 (9): 1185—6. PMC 2672629
. PMID 19261719. doi:10.1093/bioinformatics/btp121.
Literatura
[уреди | уреди извор]- Vatsis KP; Weber WW; Bell DA; et al. (1995). „Nomenclature for N-acetyltransferases.”. Pharmacogenetics. 5 (1): 1—17. PMID 7773298. doi:10.1097/00008571-199502000-00001.
- Windmill KF; McKinnon RA; Zhu X; et al. (1997). „The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies.”. Mutat. Res. 376 (1-2): 153—60. PMID 9202751. doi:10.1016/S0027-5107(97)00038-9.
- Lan Q; Rothman N; Chow WH; et al. (2003). „No apparent association between NAT1 and NAT2 genotypes and risk of stomach cancer.”. Cancer Epidemiol. Biomarkers Prev. 12 (4): 384—6. PMID 12692115.
- Ochs-Balcom HM, Wiesner G, Elston RC (2007). „A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer.”. Am. J. Epidemiol. 166 (3): 246—54. PMID 17535831. doi:10.1093/aje/kwm066.
- Sanderson S, Salanti G, Higgins J (2007). „Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis.”. Am. J. Epidemiol. 166 (7): 741—51. PMID 17675654. doi:10.1093/aje/kwm167.
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
