IDRA-21
 | |
| IUPAC ime | |
|---|---|
7-hloro-3-metil-3,4-dihidro-2H-1,2,4-benzotiadiazin 1,1-dioksid | |
| Pravni status | |
| Pravni status |
|
| Identifikatori | |
| CAS broj | 22503-72-6  |
| ATC kod | none |
| PubChem | CID 3688 |
| Sinonimi | IDRA-21 |
| Hemijski podaci | |
| Formula | C8H9ClN2O2S |
| Molarna masa | 232,68726 g/mol |
| |
IDRA-21 je ampakinski lek izveden iz aniracetama. IDRA-21 je hiralni molekul, pri čemu je (+)-IDRA-21 aktivna forma.[1]
IDRA-21 pokazuje nootropine efekte u životinjskim studijama, sa znatno poboljšanim učenjem i memorijom. On je oko 10-30 puta potentniji od aniracetama u reverznim kognitivnim deficitima indukovanim alprazolamom ili skopolaminom,[2][3] i proizvodi znatne efekte koji traju do tri dana nakon jedne doze.[4] Smatra se da je mehanizam akcije promovisanje indukcije dugotrajne potencijacije između sinapsi mozga.[5]
Reference
[uredi | uredi izvor]- ^ Uzunov, DP; Zivkovich, I; Pirkle, WH; Costa, E; Guidotti, A (1995). „Enantiomeric resolution with a new chiral stationary phase of 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide, a cognition-enhancing benzothiadiazine derivative”. Journal of pharmaceutical sciences. 84 (8): 937—42. ISSN 0022-3549. PMID 7500277. doi:10.1002/jps.2600840807.
|first2=zahteva|last2=u Authors list (pomoć);|first3=zahteva|last3=u Authors list (pomoć);|first4=zahteva|last4=u Authors list (pomoć);|first5=zahteva|last5=u Authors list (pomoć) - ^ Thompson, DM; Guidotti, A; Dibella, M; Costa, E (1995). „7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys”. Proceedings of the National Academy of Sciences of the United States of America. 92 (17): 7667—71. ISSN 0027-8424. PMC 41206
. PMID 7644474. doi:10.1073/pnas.92.17.7667. |first2=zahteva|last2=u Authors list (pomoć);|first3=zahteva|last3=u Authors list (pomoć);|first4=zahteva|last4=u Authors list (pomoć) - ^ Zivkovic, I; Thompson, DM; Bertolino, M; Uzunov, D; Dibella, M; Costa, E; Guidotti, A (1995). „7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization”. The Journal of Pharmacology and Experimental Therapeutics. 272 (1): 300—9. ISSN 0022-3565. PMID 7815345.
- ^ Buccafusco, JJ; Weiser, T; Winter, K; Klinder, K; Terry, AV (2004). „The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys”. Neuropharmacology. 46 (1): 10—22. ISSN 0028-3908. PMID 14654093. doi:10.1016/j.neuropharm.2003.07.002.
- ^ Arai, A; Guidotti, A; Costa, E; Lynch, G (1996). „Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices”. NeuroReport. 7 (13): 2211—5. ISSN 0959-4965. PMID 8930991. doi:10.1097/00001756-199609020-00031.
Vidi još
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 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
