Adalimumab
| |
| Klinički podaci | |
|---|---|
| Robne marke | Humira, Humira (Abbott Laboratories), Humira Pen |
| AHFS/Drugs.com | Monografija |
| Identifikatori | |
| CAS broj | 331731-18-1 |
| ATC kod | L04AB04 |
| DrugBank | DB00051 |
| ChEMBL[1] | CHEMBL1201580 
|
| Hemijski podaci | |
| Formula | C6428H9912N1694O1987S46 |
| Mol. masa | 144190.3 |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 10-20 dana |
| Farmakoinformacioni podaci | |
| Trudnoća | ? |
| Pravni status | |
| Način primene | Subkutano |
Adalimumab (Humira) TNF inhibirajući antiinflamatorni je lek. Adalimumab je ljudsko monoklonalno antitelo protiv TNF-alfa. On se proizvodi primenom rekombinantne DNK tehnologije koristeći sisarski ekspresioni sistem. Adalimumab se sastoji od 1330 [aminokiselina].[2][3][4][5]
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ PDB sequence Link:http://www.rcsb.org/pdb/download/downloadFile.do?fileFormat=FASTA&compression=NO&structureId=1IGT[mrtav link]
- ↑ Patent Information Link:http://www.freepatentsonline.com/6090382.html
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.
- ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.
