Ethanol enhances the mitogen-driven lymphocyte proliferation in patients with psoriasis
- PMID: 8869679
- DOI: 10.2340/0001555576260263
Ethanol enhances the mitogen-driven lymphocyte proliferation in patients with psoriasis
Abstract
Ethanol has been reported to exacerbate psoriasis. Since immunological mechanisms are considered to be important for the pathogenesis of psoriasis, we compared the effects of ethanol on lymphocyte proliferation in 15 healthy control individuals and 15 patients with psoriasis. We employed the spontaneous and phytohemagglutin in (PHA)-induced uptake of 3H-TdR to measure lymphocyte proliferation. Ethanol was added to cultures at concentrations ranging from 0.5 to 0.0005% (vol./vol.). We found that both spontaneous and PHA-driven lymphocyte proliferations were significantly lower in patients with psoriasis (P < 0.002). Spontaneous blastogenesis in both controls and patients remained stable under ethanol. In controls, ethanol suppressed the PHA-driven lymphocyte proliferation in a dose-dependent fashion. By contrast, in patients with psoriasis ethanol significantly increased lymphocyte proliferation by 2-3 times (p < 0.002). Our data indicate that in psoriasis the lower lymphocyte transformation is abnormally enhanced by minimal doses of ethanol.
Similar articles
-
Chloroquine stimulates the mitogen-driven lymphocyte proliferation in patients with psoriasis.Dermatology. 1993;187(2):100-3. doi: 10.1159/000247215. Dermatology. 1993. PMID: 8358095
-
Effects of ethyl alcohol on human peripheral lymphocytes.Arch Pathol Lab Med. 1985 Jun;109(6):540-2. Arch Pathol Lab Med. 1985. PMID: 3838884
-
Alteration of in vitro human lymphocyte function by ethanol, acetaldehyde and acetate.J Clin Lab Immunol. 1982 Oct;9(1):33-7. J Clin Lab Immunol. 1982. PMID: 7175921
-
Multiple lymphocyte transformation tests by phytohemagglutinin in healthy individuals: transient episodes of decreased lymphocyte blastogenesis.Acta Haematol. 1978;60(3):148-60. doi: 10.1159/000207711. Acta Haematol. 1978. PMID: 101002
-
Lymphocyte proliferation in response to exercise.Eur J Appl Physiol Occup Physiol. 1997;75(5):375-9. doi: 10.1007/s004210050175. Eur J Appl Physiol Occup Physiol. 1997. PMID: 9189722 Review.
Cited by
-
Advances in Relationship Between Alcohol Consumption and Skin Diseases.Clin Cosmet Investig Dermatol. 2023 Dec 29;16:3785-3791. doi: 10.2147/CCID.S443128. eCollection 2023. Clin Cosmet Investig Dermatol. 2023. PMID: 38169933 Free PMC article. Review.
-
Dietary Behaviors in Psoriasis: Patient-Reported Outcomes from a U.S. National Survey.Dermatol Ther (Heidelb). 2017 Jun;7(2):227-242. doi: 10.1007/s13555-017-0183-4. Epub 2017 May 19. Dermatol Ther (Heidelb). 2017. PMID: 28526915 Free PMC article.
-
Alcohol intake and risk of incident psoriatic arthritis in women.J Rheumatol. 2015 May;42(5):835-40. doi: 10.3899/jrheum.140808. Epub 2015 Apr 1. J Rheumatol. 2015. PMID: 25834201 Free PMC article.
-
Lifestyle Factors Involved in the Pathogenesis of Alopecia Areata.Int J Mol Sci. 2022 Jan 18;23(3):1038. doi: 10.3390/ijms23031038. Int J Mol Sci. 2022. PMID: 35162962 Free PMC article. Review.
-
Daily Lifestyle and Inflammatory Skin Diseases.Int J Mol Sci. 2021 May 14;22(10):5204. doi: 10.3390/ijms22105204. Int J Mol Sci. 2021. PMID: 34069063 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
