The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil
- PMID: 8604658
- DOI: 10.1093/ajcn/63.1.116
The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil
Abstract
The effect of a flaxseed oil-based diet on tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta) synthesis was examined in healthy volunteers. Use of flaxseed oil in domestic food preparation for 4 wk inhibited TNF alpha and IL-1 beta production by approximately 30%. Fish-oil supplementation (9 g/d) continued for a further 4 wk; TNF alpha and IL-1 beta synthesis were inhibited by 74% and 80%, respectively. There was a significant inverse exponential relation between TNF alpha or IL-1 beta synthesis and mononuclear cell content of eicosapentaenoic acid (EPA), an n--3 fatty acid derived from ingested EPA (fish oil) or metabolism of ingested alpha-linolenic acid (flaxseed oil). Cytokine production decreased as cellular EPA increased to approximately 1% of total fatty acids. Further increases in EPA content did not result in further decreases in cytokine production. The results indicate that vegetable oils rich in n--3 fatty acids inhibit TNF alpha and IL-1 beta synthesis.
Similar articles
-
Dietary polyunsaturated fatty acids and inflammatory mediator production.Am J Clin Nutr. 2000 Jan;71(1 Suppl):343S-8S. doi: 10.1093/ajcn/71.1.343s. Am J Clin Nutr. 2000. PMID: 10617994 Review.
-
Interaction between fish and vegetable oils in relation to rat leucocyte leukotriene production.J Nutr. 1991 May;121(5):631-7. doi: 10.1093/jn/121.5.631. J Nutr. 1991. PMID: 1850455
-
Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y.Am J Clin Nutr. 2001 Mar;73(3):539-48. doi: 10.1093/ajcn/73.3.539. Am J Clin Nutr. 2001. PMID: 11237929 Clinical Trial.
-
Immunologic effects of national cholesterol education panel step-2 diets with and without fish-derived N-3 fatty acid enrichment.J Clin Invest. 1993 Jul;92(1):105-13. doi: 10.1172/JCI116537. J Clin Invest. 1993. PMID: 8325975 Free PMC article.
-
Marine lipids: overview "news insights and lipid composition of Lyprinol".Allerg Immunol (Paris). 2000 Sep;32(7):261-71. Allerg Immunol (Paris). 2000. PMID: 11094639 Review.
Cited by
-
Hypericum perforatum L. (St. John's Wort) in broilers diet improve growth performance, intestinal microflora and immunity.Poult Sci. 2024 Oct 14;103(12):104419. doi: 10.1016/j.psj.2024.104419. Online ahead of print. Poult Sci. 2024. PMID: 39427421 Free PMC article.
-
Free Fatty Acid 4 Receptor Activation Attenuates Collagen-Induced Arthritis by Rebalancing Th1/Th17 and Treg Cells.Int J Mol Sci. 2024 May 28;25(11):5866. doi: 10.3390/ijms25115866. Int J Mol Sci. 2024. PMID: 38892051 Free PMC article.
-
Efficacy and safety of omega-3 fatty acids supplementation for anxiety symptoms: a systematic review and dose-response meta-analysis of randomized controlled trials.BMC Psychiatry. 2024 Jun 18;24(1):455. doi: 10.1186/s12888-024-05881-2. BMC Psychiatry. 2024. PMID: 38890670 Free PMC article.
-
Genetically predicted 486 blood metabolites concerning risk of systemic lupus erythematosus: a Mendelian randomization study.Sci Rep. 2023 Dec 18;13(1):22543. doi: 10.1038/s41598-023-49233-8. Sci Rep. 2023. PMID: 38110541 Free PMC article.
-
Reassessing the Effects of Dietary Fat on Cardiovascular Disease in China: A Review of the Last Three Decades.Nutrients. 2023 Sep 29;15(19):4214. doi: 10.3390/nu15194214. Nutrients. 2023. PMID: 37836498 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials