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. 1993 Aug;34(9):2638-45.

Sites of cone system sensitivity loss in retinitis pigmentosa

W H Seiple  1 , K Holopigian, V C Greenstein, D C Hood
Affiliations
  • PMID: 8344787

Sites of cone system sensitivity loss in retinitis pigmentosa

W H Seiple et al. Invest Ophthalmol Vis Sci. 1993 Aug.

Abstract

Purpose: To examine the sites of cone sensitivity loss in patients with retinitis pigmentosa by comparing focal electroretinographic and psychophysical modulation thresholds.

Methods: Both psychophysical and electrophysiologic increment threshold curves were obtained in retinitis pigmentosa patients and a group of age-matched, normally-sighted adults.

Results: The majority of the retinitis pigmentosa data could be accounted for by a vertical displacement of the normal curve. The retinitis pigmentosa patients showed similar patterns of cone sensitivity losses using both techniques.

Conclusions: The combined electrophysiologic and psychophysical results provide support for an outer retina locus for these cone sensitivity losses. The data suggest that these deficits may be caused by a spatially independent loss of cone photoreceptors with normal adaptation properties in the remaining photoreceptors.

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