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. 1995 Apr 25;92(9):3864-8.
doi: 10.1073/pnas.92.9.3864.

Structural interpretation of the mutations in the beta-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy

I Rayment  1 , H M Holden, J R Sellers, L Fananapazir, N D Epstein
Affiliations

Structural interpretation of the mutations in the beta-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy

I Rayment et al. Proc Natl Acad Sci U S A. .

Abstract

In 10-30% of hypertrophic cardiomyopathy kindreds, the disease is caused by > 29 missense mutations in the cardiac beta-myosin heavy chain (MYH7) gene. The amino acid sequence similarity between chicken skeletal muscle and human beta-cardiac myosin and the three-dimensional structure of the chicken skeletal muscle myosin head have provided the opportunity to examine the structural consequences of these naturally occurring mutations in human beta-cardiac myosin. This study demonstrates that the mutations are related to distinct structural and functional domains. Twenty-four are clustered around four specific locations in the myosin head that are (i) associated with the actin binding interface, (ii) around the nucleotide binding site, (iii) adjacent to the region that connects the two reactive cysteine residues, and (iv) in close proximity to the interface of the heavy chain with the essential light chain. The remaining five mutations are in the myosin rod. The locations of these mutations provide insight into the way they impair the functioning of this molecular motor and also into the mechanism of energy transduction.

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References

    1. Biochemistry. 1983 Sep 27;22(20):4696-706 - PubMed
    1. J Biol Chem. 1983 May 10;258(9):5775-86 - PubMed
    1. EMBO J. 1986 Apr;5(4):823-6 - PubMed
    1. CRC Crit Rev Biochem. 1986;21(1):53-118 - PubMed
    1. J Cell Biol. 1987 Jul;105(1):29-39 - PubMed

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