Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2024 Nov 6:15:1453083.
doi: 10.3389/fendo.2024.1453083. eCollection 2024.

Comparative study on pregnancy complications: PGT-A vs. IVF-ET with gender-specific outcomes

Ling Guo #  1   2   3 , Xiao Li #  1 , Anliang Guo #  1   2 , Yufeng Wang  2   3 , Yue Liang  2   3 , Yan Li  2   3 , Xinbo Xu  4 , Hong Lv  2   3
Affiliations
Randomized Controlled Trial

Comparative study on pregnancy complications: PGT-A vs. IVF-ET with gender-specific outcomes

Ling Guo et al. Front Endocrinol (Lausanne). .

Abstract

The safety and clinical effectiveness of preimplantation genetic testing for aneuploidy (PGT-A) in improving pregnancy outcomes for sub-fertile patients remains controversial. Potential sex-based differences in the relationship between PGT-A and pregnancy complications have not been investigated, which could guide the appropriate clinical application of PGT-A. In this secondary analysis of data from a multicenter, randomized, controlled, non-inferiority trial (NCT03118141), 940 women who achieved singleton live birth during the trial were included to estimate the between-group differences in pregnancy complications following PGT-A versus conventional in vitro fertilization (IVF) vary with fetal sex. Logistic regression analysis was used to adjust for possible confounders, and subgroup analysis was also performed. Among male fetuses, the risk of maternal preeclampsia was significantly lower after PGT-A compared to conventional IVF treatment (3.37% vs. 7.88%; adjusted OR, 0.40; 95% CI, 0.17-0.92; P = 0.032). However, this protective effect was not observed in pregnancies with female fetuses (3.63% vs. 3.38%; adjusted OR, 1.04; 95% CI, 0.36-3.00; P = 0.937). In addition, no significant sex-dependent differences in the risks of other pregnancy complications or neonatal outcomes were detected between PGT-A and conventional IVF groups (P > 0.05). In summary, PGT-A was associated with a decreased risk of maternal preeclampsia in singleton pregnancies with male fetuses, highlighting its potential utility in preeclampsia prevention in addition to spontaneous abortion rate reduction.

Keywords: fetal sex; in vitro fertilization and embryo transfer; preeclampsia; preimplantation genetic testing for aneuploidy; singleton pregnancy.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of participants screening and enrollment. IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection; PGT-A, preimplantation genetic testing for aneuploidy.
Figure 2
Figure 2
The risk of pregnancy complications based on fetal sex. (A) The risk of pregnancy complications in male fetuses. (B) The risk of pregnancy complications in female fetuses. OR > 1 indicates a risk factor, and OR < 1 indicates a protective factor.
See this image and copyright information in PMC

References

    1. Sciorio R, Tramontano L, Catt J. Preimplantation genetic diagnosis (PGD) and genetic testing for aneuploidy (PGT-A): status and future challenges. Gynecol Endocrinol. (2020) 36:6–11. doi: 10.1080/09513590.2019.1641194 - DOI - PubMed
    1. Gleicher N, Patrizio P, Brivanlou A. Preimplantation genetic testing for aneuploidy - a castle built on sand. Trends Mol Med. (2021) 27:731–42. doi: 10.1016/j.molmed.2020.11.009 - DOI - PubMed
    1. Yang Z, Liu J, Collins GS, Salem SA, Liu X, Lyle SS, et al. . Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study. Mol Cytogenet. (2012) 5:24. doi: 10.1186/1755-8166-5-24 - DOI - PMC - PubMed
    1. Rubio C, Bellver J, Rodrigo L, Castillon G, Guillen A, Vidal C, et al. . In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study. Fertil Steril. (2017) 107:1122–9. doi: 10.1016/j.fertnstert.2017.03.011 - DOI - PubMed
    1. Yan J, Qin Y, Zhao H, Sun Y, Gong F, Li R, et al. . Live birth with or without preimplantation genetic testing for aneuploidy. N Engl J Med. (2021) 385:2047–58. doi: 10.1056/NEJMoa2103613 - DOI - PubMed

Publication types

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from the National Key Research and Development Program of China (2022YFC2702400).

LinkOut - more resources