Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2021 Jan-Mar;14(1):111-117.
doi: 10.25122/jml-2020-0014.

Comparison of the effectiveness of Satureja khuzestanica and clotrimazole vaginal creams for the treatment of vulvovaginal candidiasis

Shirin Jaldani  1 , Mahnaz Fatahinia  2   2 , Elham Maraghi  3 , Eskandar Moghimipour  4 , Mojgan Javadnoori  5
Affiliations
Randomized Controlled Trial

Comparison of the effectiveness of Satureja khuzestanica and clotrimazole vaginal creams for the treatment of vulvovaginal candidiasis

Shirin Jaldani et al. J Med Life. 2021 Jan-Mar.

Erratum in

Abstract

Candidal vaginitis has a relatively high prevalence, and its resistance to treatment is on the rise. Considering the complications of chemical drugs, the use of herbal medicines has now been favored due to the lack of changes in the normal vaginal flora. The aim of this study was to compare the effectiveness of Satureja khuzestanica and clotrimazole vaginal creams for the treatment of candidal vulvovaginitis. A randomized clinical trial was conducted on 84 reproductive-aged women in the city of Ahvaz, Iran. Individuals were randomly divided into two treatment groups: 1% Satureja khuzestanica vaginal creams (n=42) and 1% clotrimazole vaginal cream (n=42) who used a one-full applicator daily for one week. About 4-7 days after the end of treatment, a clinical examination and laboratory re-tests were performed to determine the level of treatment. The data were analyzed using the Mann-Whitney U, t-test and Chi-square tests, with SPSS version 22. After the treatment, no significant difference was observed between the two groups in terms of vaginal discharge (p = 0.32), vaginal itching (p = 0.26), dysuria (p = 0.99) and dyspareunia (p = 0.60). Moreover, the results of culture (p = 0.62) and smear (p = 0.58) were not statistically significant in the two groups. Also, there was no significant difference between the two groups in terms of complete recovery after the treatment (p = 0.35). Satureja khuzestanica seems to have the same effect as clotrimazole in improving the symptoms of vaginal candidiasis, the negative results of culture and smear, as well as complete treatment.

Keywords: Satureja Khuzestanica; candidal vulvovaginitis; clotrimazole.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Study diagram.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Vicariotto F, Del Piano M, Mogna L, Mogna G. Effectiveness of the association of 2 probiotic strains formulated in a slow release vaginal product, in women affected by vulvovaginal candidiasis: a pilot study. Journal of clinical gastroenterology. 2012;46:S73–S80. - PubMed
    1. Bornstein J, Zarfati D. A universal combination treatment for vaginitis. Obstetrical & Gynecological Survey. 2008;63(9):570–571.
    1. Buitrón RG, Romero RC, Cruz FT, Bonifaz A, Zarama FM. Study on Candida no-albicans species and its relation to recurrent vulvovaginal candidiasis. Ginecologia y obstetricia de Mexico. 2002;70:431–436. - PubMed
    1. Sobel JD. Vulvovaginal candidosis. The Lancet. 2007;369(9577):1961–1971. - PubMed
    1. Weissenbacher T, Witkin S, Ledger W, et al. Relationship between clinical diagnosis of recurrent vulvovaginal candidiasis and detection of Candida species by culture and polymerase chain reaction. Archives of gynecology and obstetrics. 2009;279(2):125–129. - PubMed

Publication types

LinkOut - more resources