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. 2017 Winter;29(1):45-51.
doi: 10.1176/appi.neuropsych.15120403. Epub 2016 Aug 19.

The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis

Adalia H Jun-O'Connell  1 , Ankur Butala  1 , Idanis Berrios Morales  1 , Nils Henninger  1 , Kristina M Deligiannidis  1 , Nancy Byatt  1 , Carolina Ionete  1
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The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis

Adalia H Jun-O'Connell et al. J Neuropsychiatry Clin Neurosci. 2017 Winter.

Abstract

Clinical observations of mood instability in multiple sclerosis (MS) have led to the hypothesis that bipolar disorder (BD) may be more prevalent in persons with MS than in the general population. This cross-sectional study assesses the prevalence of BD among patients with MS using standardized psychiatric diagnostic interviews and evaluates quality of life. This study demonstrates a higher prevalence of BD in patients with MS compared with the general population. It also reveals the negative impact of BD on quality of life, raises the concern that BD can occur before the onset of neurological symptoms in MS, and suggests that, in some cases, BD may delay diagnosis of MS.

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References

    1. Compston A, Coles A. Multiple sclerosis. Lancet. 2002;359(9313):1221–31. - PubMed
    1. Asghar-Ali AA, Taber KH, Hurley RA, Hayman LA. Pure neuropsychiatric presentation of multiple sclerosis. The American journal of psychiatry. 2004;161(2):226–31. - PubMed
    1. Hurley RA, Taber KH, Zhang J, Hayman LA. Neuropsychiatric presentation of multiple sclerosis. The Journal of neuropsychiatry and clinical neurosciences. 1999;11(1):5–7. - PubMed
    1. Byatt N, Rothschild AJ, Riskind P, Ionete C, Hunt AT. Relationships between multiple sclerosis and depression. The Journal of neuropsychiatry and clinical neurosciences. 2011;23(2):198–200. - PubMed
    1. Johansson V, Lundholm C, Hillert J, Masterman T, Lichtenstein P, Landen M, et al. Multiple sclerosis and psychiatric disorders: comorbidity and sibling risk in a nationwide Swedish cohort. Multiple sclerosis. 2014;20(14):1881–91. - PubMed