Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2011 Aug;68(8):827-37.
doi: 10.1001/archgenpsychiatry.2011.37. Epub 2011 Apr 4.

Ten-year course of borderline personality disorder: psychopathology and function from the Collaborative Longitudinal Personality Disorders study

John G Gunderson  1 , Robert L Stout, Thomas H McGlashan, M Tracie Shea, Leslie C Morey, Carlos M Grilo, Mary C Zanarini, Shirley Yen, John C Markowitz, Charles Sanislow, Emily Ansell, Anthony Pinto, Andrew E Skodol
Affiliations
Comparative Study

Ten-year course of borderline personality disorder: psychopathology and function from the Collaborative Longitudinal Personality Disorders study

John G Gunderson et al. Arch Gen Psychiatry. 2011 Aug.

Abstract

Context: Borderline personality disorder (BPD) is traditionally considered chronic and intractable.

Objective: To compare the course of BPD's psychopathology and social function with that of other personality disorders and with major depressive disorder (MDD) over 10 years.

Design: A collaborative study of treatment-seeking, 18- to 45-year-old patients followed up with standardized, reliable, and repeated measures of diagnostic remission and relapse and of both global social functioning and subtypes of social functioning.

Setting: Nineteen clinical settings (hospital and outpatient) in 4 northeastern US cities.

Participants: Three study groups, including 175 patients with BPD, 312 with cluster C personality disorders, and 95 with MDD but no personality disorder.

Main outcome measures: The Diagnostic Interview for DSM-IV Personality Disorders and its follow-along version (the Diagnostic Interview for DSM-IV Personality Disorders-Follow-Along Version) were used to diagnose personality disorders and assess changes in them. The Structured Clinical Interview for DSM-IV Axis I Disorders and the Longitudinal Interval Follow-up Evaluation were used to diagnose MDD and assess changes in MDD and in social function.

Results: Eighty-five percent of patients with BPD remitted. Remission of BPD was slower than for MDD (P < .001) and minimally slower than for other personality disorders (P < .03). Twelve percent of patients with BPD relapsed, a rate less frequent and slower than for patients with MDD (P < .001) and other personality disorders (P = .008). All BPD criteria declined at similar rates. Social function scores showed severe impairment with only modest albeit statistically significant improvement; patients with BPD remained persistently more dysfunctional than the other 2 groups (P < .001). Reductions in criteria predicted subsequent improvements in DSM-IV Axis V Global Assessment of Functioning scores (P < .001).

Conclusions: The 10-year course of BPD is characterized by high rates of remission, low rates of relapse, and severe and persistent impairment in social functioning. These results inform expectations of patients, families, and clinicians and document the severe public health burden of this disorder.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Diagnostic remission (A) and diagnostic relapse (B) of major depressive disorder (MDD), other personality disorders (OPD; either avoidant personality disorder [AVPD] or obsessive-compulsive personality disorder [OCPD]), and borderline personality disorder (BPD). Remission of MDD was based on a Psychiatric Status Rating of less than 2 for 2 consecutive months, and MDD relapse was based on a Psychiatric Status Rating of 5 or 6 for 2 consecutive months. Remission of OPD was defined as either fewer than 2 AVPD criteria for AVPD cases or fewer than 2 OCPD criteria for OCPD cases for 2 or 12 consecutive months, and OPD relapse was defined as returning to more than 4 criteria for 2 months or for either AVPD or OCPD cases separately. Remission of BPD was defined as fewer than 2 criteria for 2 or 12 consecutive months, and BPD relapse was defined as returning to more than 5 criteria for 2 months. Analyses were based on lifetest survival estimates.
Figure 2
Figure 2
Prevalence of borderline personality disorder criteria. Positive indicates the cases with a score of 2 (definitely present and clinically significant) for each of the 9 borderline personality disorder criteria on the Diagnostic Interview for DSM-IV Personality Disorders, assessed for the 2 years prior to the follow-up point.
Figure 3
Figure 3
Scores on the Global Assessment of Functioning (GAF) (A) and the Global Social Adjustment (GSA) scale (B). A, A score of 100 represents the best level of overall functioning, and a score of 0 represents the lowest level. B, A score of 0 represents the highest level of social functioning, and a score of 5 represents the lowest level. MDD indicates major depressive disorder; OPD, other personality disorders; and BPD, borderline personality disorder.
Figure 4
Figure 4
Functional remission, defined as a Global Assessment of Functioning score greater than 70 sustained for 2 months. Analyses were conducted using lifetest survival estimates. MDD indicates major depressive disorder; OPD, other personality disorders; and BPD, borderline personality disorder.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Grilo CM, McGlashan TH, Oldham JM. Course and stability of personality disorders. J Pract Psychiatry Behav Health. 1998;1(4):61–75.
    1. Robins E, Guze SB. Establishment of diagnostic validity in psychiatric illness: its application to schizophrenia. Am J Psychiatry. 1970;126(7):983–987. - PubMed
    1. Gunderson JG, Shea MT, Skodol AE, McGlashan TH, Morey LC, Stout RL, Zanarini MC, Grilo CM, Oldham JM, Keller MB. The Collaborative Longitudinal Personality Disorders Study: development, aims, design, and sample characteristics. J Pers Disord. 2000;14(4):300–315. - PubMed
    1. Zanarini MC, Frankenburg FR, Reich DB, Fitzmaurice G. Time to attainment of recovery from borderline personality disorder and stability of recovery: a 10-year prospective follow-up study. Am J Psychiatry. 2010;167(6):663–667. - PMC - PubMed
    1. Zanarini MC, Frankenburg FR, Reich DB, Fitzmaurice G. The 10-year course of psychosocial functioning among patients with borderline personality disorder and axis II comparison subjects. Acta Psychiatr Scand. 2010;122(2):103–109. - PMC - PubMed

Publication types