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Clinical Trial
. 2005 Jan;54(1):158-65.
doi: 10.2337/diabetes.54.1.158.

Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study

David E Laaksonen  1 , Jaana Lindström, Timo A Lakka, Johan G Eriksson, Leo Niskanen, Katja Wikström, Sirkka Aunola, Sirkka Keinänen-Kiukaanniemi, Mauri Laakso, Timo T Valle, Pirjo Ilanne-Parikka, Anne Louheranta, Helena Hämäläinen, Merja Rastas, Virpi Salminen, Zygimantas Cepaitis, Martti Hakumäki, Hannu Kaikkonen, Pirjo Härkönen, Jouko Sundvall, Jaakko Tuomilehto, Matti Uusitupa; Finnish diabetes prevention study
Affiliations
Clinical Trial

Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study

David E Laaksonen et al. Diabetes. 2005 Jan.

Abstract

Clinical trials have demonstrated that lifestyle changes can prevent type 2 diabetes, but the importance of leisure-time physical activity (LTPA) is still unclear. We carried out post hoc analyses on the role of LTPA in preventing type 2 diabetes in 487 men and women with impaired glucose tolerance who had completed 12-month LTPA questionnaires. The subjects were participants in the Finnish Diabetes Prevention Study, a randomized controlled trial of lifestyle changes including diet, weight loss, and LTPA. There were 107 new cases of diabetes during the 4.1-year follow-up period. Individuals who increased moderate-to-vigorous LTPA or strenuous, structured LTPA the most were 63-65% less likely to develop diabetes. Adjustment for changes in diet and body weight during the study attenuated the association somewhat (upper versus lower third: moderate-to-vigorous LTPA, relative risk 0.51, 95% CI 0.26-0.97; strenuous, structured LTPA, 0.63, 0.35-1.13). Low-intensity and lifestyle LTPA and walking also conferred benefits, consistent with the finding that the change in total LTPA (upper versus lower third: 0.34, 0.19-0.62) was the most strongly associated with incident diabetes. Thus increasing physical activity may substantially reduce the incidence of type 2 diabetes in high-risk individuals.

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