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. 1992;51(25):1953-6.
doi: 10.1016/0024-3205(92)90112-3.

Increase of plasma IL-6 concentration with age in healthy subjects

J Wei  1 , H Xu, J L Davies, G P Hemmings
Affiliations

Increase of plasma IL-6 concentration with age in healthy subjects

J Wei et al. Life Sci. 1992.

Abstract

The present study demonstrated that plasma IL-6 concentration was higher in older subjects than in younger ones and significantly in the male group (P = 0.02); Spearman rank correlation showed that plasma IL-6 concentration was positively correlated with age (r = 0.28, N = 55, P < 0.05); there was a highly significant correlation between the concentrations in plasma IL-6 and IL-1 alpha (r = 0.51, N = 52, P < 0.001). These findings suggest the possibility that age-related changes of plasma IL-6 and IL-1 alpha may provide a pathological basis for the susceptibility to such illness as commonly occurs in elderly people, especially Alzheimer's disease as the two interleukins can induce the production of alpha 1-antichymotrypsin and beta-amyloid protein precursor.

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