[Role of Lactobacillus as protector against vaginal candidiasis]
- PMID: 11571120
- DOI: 10.1016/s0025-7753(01)72089-1
[Role of Lactobacillus as protector against vaginal candidiasis]
Abstract
Background: To evaluate the possible protector role of Lactobacillus against vaginal candidiasis.
Patients and method: In vitro studies performed to assess the capacity of 15 Lactobacillus strains to block the adhesion of two Candida albicans and one C. glabrata strain to vaginal epithelial cells and to inhibit the growth of these yeasts. Moreover, the presence of Lactobacillus was analyzed in 115 vaginal exudates from women with vaginal candidiasis.
Results: Only 8 of the 15 lactobacilli studied significantly blocked the adhesion of C. albicans Y18 to vaginal cells. Lactobacilli from group III showed the greatest blocking capacity (62.9%), followed by group II (50.6%) and group I (26.1%). In solid assays, none of the 15 Lactobacillus strains studied was able to inhibit growth of the 3 yeasts. However, in liquid assays some lactobacilli evidenced a certain degree of inhibitory power against C. albicans Y17 (35.7%, 41.7% and 38.1% of light transmittance for Lactobacillus groups I, II and III, respectively). Lactobacillus was detected in 89.6% of women with vaginal candidiasis (by microscopy in 87.8% and by culture in 72.2%).
Conclusions: These results lead us to suggest that probably Lactobacillus provides protection against vaginal candidiasis.
Similar articles
-
Study of Candida albicans strains isolated from women with various forms of vaginal candidiasis.Bull Exp Biol Med. 2003 Mar;135(3):276-80. doi: 10.1023/a:1024145300447. Bull Exp Biol Med. 2003. PMID: 12802401
-
Can Lactobacillus acidophilus influence the adhesion capacity of Candida albicans on the combined contraceptive vaginal ring?Contraception. 2010 Apr;81(4):331-5. doi: 10.1016/j.contraception.2009.12.011. Epub 2010 Jan 22. Contraception. 2010. PMID: 20227551
-
Anti-Candida activity of beneficial vaginal lactobacilli in in vitro assays and in a murine experimental model.FEMS Yeast Res. 2019 Mar 1;19(2):foz008. doi: 10.1093/femsyr/foz008. FEMS Yeast Res. 2019. PMID: 30689833
-
Probiotics for prevention of recurrent vulvovaginal candidiasis: a review.J Antimicrob Chemother. 2006 Aug;58(2):266-72. doi: 10.1093/jac/dkl246. Epub 2006 Jun 21. J Antimicrob Chemother. 2006. PMID: 16790461 Review.
-
A molecular view on the interference established between vaginal Lactobacilli and pathogenic Candida species: Challenges and opportunities for the development of new therapies.Microbiol Res. 2024 Apr;281:127628. doi: 10.1016/j.micres.2024.127628. Epub 2024 Jan 19. Microbiol Res. 2024. PMID: 38246122 Review.
Cited by
-
Differential alteration in Lactiplantibacillus plantarum subsp. plantarum quorum-sensing systems and reduced Candida albicans yeast survival and virulence gene expression in dual-species interaction.Microbiol Spectr. 2024 Jun 4;12(6):e0035324. doi: 10.1128/spectrum.00353-24. Epub 2024 May 8. Microbiol Spectr. 2024. PMID: 38717160 Free PMC article.
-
Acetate modulates the inhibitory effect of Lactobacillus gasseri against the pathogenic yeasts Candida albicans and Candida glabrata.Microb Cell. 2023 Mar 21;10(4):88-102. doi: 10.15698/mic2023.04.795. eCollection 2023 Apr 3. Microb Cell. 2023. PMID: 37009625 Free PMC article.
-
Vulvovaginal candidiasis and vaginal microflora interaction: Microflora changes and probiotic therapy.Front Cell Infect Microbiol. 2023 Feb 3;13:1123026. doi: 10.3389/fcimb.2023.1123026. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 36816582 Free PMC article. Review.
-
An optimized electrotransformation protocol for Lactobacillus jensenii.PLoS One. 2023 Feb 17;18(2):e0280935. doi: 10.1371/journal.pone.0280935. eCollection 2023. PLoS One. 2023. PMID: 36800374 Free PMC article.
-
Bacterial-fungal interactions and their impact on microbial pathogenesis.Mol Ecol. 2023 May;32(10):2565-2581. doi: 10.1111/mec.16411. Epub 2022 Mar 14. Mol Ecol. 2023. PMID: 35231147 Free PMC article. Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources