Dr. Lincoln Stein
Contact
Dr. Lincoln Stein
Acting Scientific Director, and Head, Adaptive Oncology
Michelle Xin
Executive Assistant, Adaptive Oncology
[email protected]
Acting Scientific Director, and Head, Adaptive Oncology
Dr. Lincoln Stein focuses on supporting biomedical research both in Ontario and around the world by making large and complex biological datasets findable, accessible and usable.
External Links
Prior to joining OICR in 2006, Dr. Stein played an integral role in many large-scale data initiatives at Cold Spring Harbor Laboratory and at the Massachusetts Institute of Technology (MIT) Genome Center. He led the development of the first physical clone map of the human genome, and ran the data coordinating centre and the data portal for the SNP Consortium and the HapMap Consortium. Dr. Stein has also led the creation and development of Wormbase, a community model organism database for C. elegans, and Reactome, which is now the largest open community database of biological reactions and pathways.
At OICR, Dr. Stein has led several international cancer data sharing and research initiatives, including the creation and development of the data coordination centre for the International Cancer Genome Consortium and other related projects. He continues to collaborate with national and international partners to create and promote data sharing standards, protocols and implementations.
Experience & Education
- Program Director, Informatics and Bio-computing, OICR
- Professor, Cold Spring Harbor, New York
- Associate Professor, Cold Spring Harbor, New York
- Director Information Systems, CuraGen Corporation
- Instructor, Harvard Medical School, Deptartment of Pathology, Brigham and Women’s Hospital
- Director, Informatics Core, MIT Genome Center, Whitehead Institute for Biomedical Research, MIT
- Residency, Anatomic Pathology, Brigham and Women’s Hospital
- MD, Harvard Medical School
- PhD, Cell Biology, Harvard University
Current Affiliations
- Acting Scientific Director, OICR
- Head, Adaptive Oncology, OICR
- Chair of the International Cancer Genome Consortium Executive Committee, International Scientific Steering Committee and Data Coordination and Management Committee
- Member of the Pan Cancer Analysis of Whole Genomes (PCAWG) Steering Committee
- Member of the ICGCmed Scientific Planning Committee Data Coordination and Management Committee
- Professor, Department of Molecular Genomics, University of Toronto
Select Publications
- Shuai S, Suzuki H, Diaz-navarro A, …, Stein LD. The U1 spliceosomal RNA is recurrently mutated in multiple cancers. Nature. 2019;574(7780):712-716.
- Vladoiu MC, El-hamamy I, Donovan LK, …, Stein L, Taylor MD. Childhood cerebellar tumours mirror conserved fetal transcriptional programs. Nature. 2019;572(7767):67-73.
- Shlush LI, Zandi S, Mitchell A, …, Stein LD, …, Dick JE. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature. 2014;506(7488):328-33.
- Gonzalez-Perez A, Mustonen V, Reva B, …, Stein LD, Lopez-Bigas N; International Cancer Genome Consortium Mutation Pathways and Consequences Subgroup of the Bioinformatics Analyses Working Group. Computational approaches to identify functional genetic variants in cancer genomes. Nat Methods. 2013;10(8):723-9.
- Trinh QM, Jen FY, Zhou Z, …, Stein LD. Cloud-based uniform ChIP-Seq processing tools for modENCODE and ENCODE. BMC Genomics. 2013;14:494.
See Dr. Stein’s recent publications on PubMed or on Google Scholar.
Research Areas
Disease Areas
Awards
Dr. Stein was named one of the World’s Most Influential Scientific Minds by Thompson Reuters in 2014 and a Fellow of the International Society of Computational Biology (ISCB) in 2016. He was recently awarded the Canadian Cancer Research Alliance’s Outstanding Achievements in Cancer Research Award (2019).
Opportunities to Collaborate
Visit OICR’s Collaborative Research Resources directory for more opportunities to collaborate with OICR researchers.
Tools
In the News
With astonishing speed, OICR team creates national COVID-19 genomic data portal
May 07, 2021
OICR to contribute to new Canadian COVID-19 data portal
Apr 08, 2021
New prognostic biomarkers and cancer-driving genes found in the dark matter of the cancer genome
Nov 15, 2021
Two OICR innovations bolstered by investments from FACIT
Apr 28, 2022
International Cancer Genome Consortium empowers cancer researchers everywhere with new cloud computing platform
Nov 23, 2021
Three OICR scientists make ‘highly cited researchers’ list
Nov 15, 2022
Zooming in on mouse brain development reveals origins of human glial cancers
Dec 08, 2022
OICR-led data resource deemed ‘critical’ to global biomedical research
Dec 15, 2022
OICR researchers join Lancet commission to tackle inequities in precision cancer care
Feb 02, 2023
Ask a Cancer Researcher: Why do we sequence tumour DNA?
Apr 26, 2023
New funding partnership with U of T Data Sciences Institute aims to drive new breakthroughs
Jun 20, 2023
First-ever national library of genomic data will help personalize cancer treatment in Canada and around the world
Oct 27, 2023
National conference helps OICR PhD students shape their research and their futuresÂ
Nov 23, 2023
Student-developed machine learning model can predict how medicines treat different tumours
Apr 16, 2024
How two cancers make themselves harder to treat by suppressing the immune system
Apr 22, 2024
Ask a Cancer Researcher: Why is it so challenging to find a cure for cancer?
Jun 13, 2024
Longtime OICR Executives to lead Institute through important new chapter
Nov 11, 2024
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