OLIG2

OLIG2
Identifikatorar
Andre namn	OLIG2, BHLHB1, OLIGO2, PRKCBP2, RACK17, bHLHe19, oligodendrocyte lineage transcription factor 2, oligodendrocyte transcription factor 2
Eksterne ID-ar	OMIM: 606386 MGI: 1355331 HomoloGene: 4241 GeneCards: OLIG2
Genplassering (menneske)
Kromosom	Menneskekromosom 21
Ende	33,029,196 bp
Genplassering (mus)
Kromosom	Musekromosom 16
Ende	91,025,565 bp
RNA-uttrykksmønster
	Top expressed in
	inferior ganglion of vagus nerve; ; globus pallidus; ; globus pallidus medialis; ; amygdala; ; ventral tegmental area; ; nucleus subthalamicus; ; globus pallidus lateralis; ; substantia nigra; ; 1. cervikalsegment; ; hippocampus proper;
	Meir referanseuttrykksdata
	; ;
	More reference expression data
Genontologi
Molekylær funksjon	DNA-binding; protein dimerization activity; protein homodimerization activity; GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; HMG box domain binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Sellekomponent	cytoplasma; cellekjerne;
Biologisk prosess	positive regulation of oligodendrocyte differentiation; GO:0009373 regulation of transcription, DNA-templated; negative regulation of neuron differentiation; thalamus development; spinal cord oligodendrocyte cell fate specification; oligodendrocyte differentiation; GO:1901227 negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; utvikling av nervesystem; utvikling i fleircella organisme; oligodendrocyte cell fate specification; differensiering av nervecelle; myelination; neuron fate commitment; spinal cord motor neuron differentiation; spinal cord oligodendrocyte cell differentiation;
	Kjelder:Amigo / QuickGO
Ortologar
	10215
	50913
	ENSG00000205927
	ENSMUSG00000039830
	Q13516
	Q9EQW6
	NM_005806
	NM_016967
	NP_005797
	NP_058663
	Wikidata
sjå/endra menneske	sjå/endra mus

OLIG2 eller oligodendrocytt-transkripsjonsfaktor 2 er ein basisk heliks-lykkje-heliks (bHLH)-hovudtranskripsjonsfaktor og repressor som styrer utviklinga av oligodendrocyttar. Til liks med OLIG1 dannar han sterke homodimerar og veike heterodimerar med bHLH-proteina E12 og E47. OLIG2 dannar òg kompleks med bHLH-transkripsjonsfaktoren neurogenin 2.^[5]^[6]

OLIG2-genet finst hjå pattedyr, krypdyr, fuglar, amfibium, ekte beinfiskar og bruskfiskar. Det er ukjent om OLIG2 og andre OLIG-protein finst hjå kjevelause fiskar.^[5]

Kjelder

↑ ^1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000205927 - Ensembl, May 2017
↑ ^2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000039830 - Ensembl, May 2017
↑ «PubMed-kjelde for menneske:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ «PubMed-kjelde for mus:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ ^5,0 ^5,1 Li, Huiliang; Richardson, William D. (2009). «The evolution of Olig genes and their roles in myelination». Neuron Glia Biology 4 (2): 129. PMID 19737433. doi:10.1017/S1740925X09990251.
↑ Xin, M.; Yue, T; Ma, Z; Wu, F. F.; Gow, A; Lu, Q. R. (2005). «Myelinogenesis and Axonal Recognition by Oligodendrocytes in Brain Are Uncoupled in Olig1-Null Mice». Journal of Neuroscience 25 (6): 1354–65. PMID 15703389. doi:10.1523/JNEUROSCI.3034-04.2005.

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[refGRCh38Ensembl-1] 1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000205927 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000039830 - Ensembl, May 2017

[3] «PubMed-kjelde for menneske:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] «PubMed-kjelde for mus:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[Li2008-5] 5,0 ^5,1 Li, Huiliang; Richardson, William D. (2009). «The evolution of Olig genes and their roles in myelination». Neuron Glia Biology 4 (2): 129. PMID 19737433. doi:10.1017/S1740925X09990251.

[6] Xin, M.; Yue, T; Ma, Z; Wu, F. F.; Gow, A; Lu, Q. R. (2005). «Myelinogenesis and Axonal Recognition by Oligodendrocytes in Brain Are Uncoupled in Olig1-Null Mice». Journal of Neuroscience 25 (6): 1354–65. PMID 15703389. doi:10.1523/JNEUROSCI.3034-04.2005.

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