Journal
Amino Acids
Amino Acids is an international, fully open access, peer-reviewed journal dedicated to publishing high-quality research related to the chemistry, biochemistry, physiology,...
The interruption of amino acids supply has emerged as a promising anti-tumor strategy, with research focusing on the metabolic vulnerabilities of cancer cells. Depletion of essential amino acids necessary for tumor growth has shown potential in inhibiting cancer cell proliferation and inducing cell death. This approach has garnered significant interest in the field of cancer metabolism and targeted therapies, with studies exploring the mechanisms underlying amino acid depletion’s anti-tumor effects and its potential as a therapeutic strategy across different cancer types.
Advancing our collective understanding in this area is crucial for identifying novel therapeutic targets and developing effective anti-cancer interventions. Recent advances have elucidated the intricate metabolic pathways involved in amino acid utilization by cancer cells, shedding light on the potential for targeted disruption of amino acid metabolism and supply as a strategy to impede tumor growth. Furthermore, studies have highlighted the interplay between amino acid depletion and the tumor microenvironment, offering insights into the broader implications of this approach for cancer therapy.
Original Research articles and reviews in this field are invited.
This Collection supports and amplifies research related to SDG 3 (Good Health and Well-being).
Submit your manuscript to this collection through the participating journal.
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Ellen Closs
Prof. Dr. Ellen Closs studied biology in Gießen, Heidelberg, and Vienna, earning her PhD at LMU Munich. After a four-year research stint at Harvard Medical School, she established a research group at the Institute of Pharmacology in Mainz. She completed her habilitation in 1998 and became an Adjunct Professor in 2005. Passionate about gender equality, she has worked to support women in academia, serving as Gender Equality Officer at the University Medical Center Mainz, co-founding a mentoring program, and participating in various equality committees. -
Stefan Broer
Prof. Dr. Stefan Broer studied Biochemistry at the University of Tuebingen (1981-1986) and earned his Master's in 1987. He completed his PhD in 1991, researching amino acid-producing bacteria at the Research Center in Juelich. After a postdoctoral fellowship at the University of Illinois in Chicago, he became a Junior Lecturer at the University of Tuebingen's Institute of Physiological Chemistry in 1993 and was promoted to Senior Lecturer in 1998. In 2000, he joined ANU as a Senior Lecturer, becoming an Associate Professor in 2006 and a full Professor in 2008. He has published over 150 papers on amino acid transport and metabolism.
