As this Bloomberg map shows, Malaysian flight 370 is not the first flight to mysteriously disappear. 83 flights have vanished since 1948—80 of them never to be found again (the dots in yellow). This map only includes flights capable of carrying more than 14 passengers.
Some more curious stats:
Five planes were missing in the famous Bermuda Triangle.
The DC-3 is the airplane with the higher count of disappearances: 19.
The average number of people missing: 13.
The average number of vanished flight per year: 1.2.
Check out the full Bloomberg infographic here.