The Tsodyks-Markram model of short-term plasticity underwent many changes in the last twenty years. In this folder we provide 2 examples to fit 2 different versions using BluePyOpt.

tsodyksmarkramstp.ipynb numerically integrates the "full version" of the TM model and fits a postsynaptic voltage trace.

tsodyksmarkramstp_multiplefreqs.ipynb implements the event-based solution of the (reduced, but) more common version of the TM model and fits amplitudes from multiple stimulation frequencies for better generalization.