%PDF-1.4
%âãÏÓ
241 0 obj
<>
endobj
240 0 obj
<>stream
2017-04-17T20:07:31+05:30
Arbortext Advanced Print Publisher 10.0.1465/W Unicode
2024-11-29T14:48:25-08:00
2024-11-29T14:48:25-08:00
Acrobat Distiller 9.0.0 (Windows)
application/pdf
<alt>
<li xml:lang="x-default">Canu: scalable and accurate long-read assembly via adaptive k-mer weighting and repeat separation</li>
</alt>
uuid:84891b25-db5b-4b19-bcc3-bca4ef8a9fe4
uuid:c69f7246-1dd1-11b2-0a00-bf00b878edff
endstream
endobj
236 0 obj
<>
endobj
238 0 obj
<>
endobj
2 0 obj
<>
endobj
141 0 obj
<>
endobj
140 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Type/Page>>
endobj
179 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
183 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
197 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
214 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
280 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
301 0 obj
[308 0 R 309 0 R 310 0 R 311 0 R 312 0 R 313 0 R 314 0 R 315 0 R 316 0 R]
endobj
302 0 obj
<>stream
q
300 0 0 75 164 679 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
10 0 0 10 344.36975 580.99982 Tm
( )Tj
0 0 1 rg
-10.34099 0 Td
(10.1101/gr.215087.116)Tj
0 g
-16.89599 0 Td
(Access the most recent version at doi:)Tj
6.447 1 Td
(2017 27: 722-736 originally published online March 15, 2017)Tj
/T1_1 1 Tf
-6.447 0 Td
(Genome Res.\240)Tj
/T1_0 1 Tf
0 1.00001 TD
(\240 )Tj
0 1 TD
(Sergey Koren, Brian P. Walenz, Konstantin Berlin, et al. )Tj
T*
(\240 )Tj
/T1_2 1 Tf
15 0 0 15 72 630.99997 Tm
(weighting and repeat separation)Tj
30.01189 1 Td
(-mer)Tj
/T1_3 1 Tf
-0.556 0 Td
(k)Tj
/T1_2 1 Tf
-29.45589 0 Td
(Canu: scalable and accurate long-read assembly via adaptive )Tj
ET
72 569 m
556 569 l
0 0 m
S
BT
ET
BT
/T1_0 1 Tf
11 0 0 11 156.942 523.99994 Tm
(\240 )Tj
/T1_2 1 Tf
-3.50099 1 Td
(Material)Tj
-2.77799 1.00001 Td
(Supplemental)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 177 536.99997 Tm
(\240 )Tj
32.62186 1 Td
( )Tj
0 0 1 rg
/T1_2 1 Tf
-32.62186 0 Td
(http://genome.cshlp.org/content/suppl/2017/04/05/gr.215087.116.DC1)Tj
ET
BT
0 g
/T1_0 1 Tf
11 0 0 11 156.942 492.99997 Tm
(\240 )Tj
/T1_2 1 Tf
-5.11299 1 Td
(References)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 177 484.99994 Tm
(\240 )Tj
28.11684 1 Td
( )Tj
0 0 1 rg
/T1_2 1 Tf
-28.11684 0 Td
(http://genome.cshlp.org/content/27/5/722.full.html#ref-list-1)Tj
0 g
/T1_0 1 Tf
0 1.00001 TD
(This article cites 69 articles, 16 of which can be accessed free at:)Tj
ET
BT
/T1_0 1 Tf
11 0 0 11 156.942 462.99997 Tm
(\240 )Tj
/T1_2 1 Tf
-6.05798 1 Td
(Open Access)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 177 464.99997 Tm
(\240 )Tj
23.95496 1 Td
( Open Access option.)Tj
/T1_1 1 Tf
-8.39198 0 Td
(Genome Research)Tj
/T1_0 1 Tf
-15.56298 0 Td
(Freely available online through the )Tj
ET
BT
/T1_0 1 Tf
11 0 0 11 164.94208 414.99991 Tm
(\240 )Tj
/T1_2 1 Tf
-3.44598 1 Td
(License)Tj
-1.16501 1.00001 Td
(Commons )Tj
0.94299 1 Td
(Creative)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 375.29962 428.99994 Tm
(.)Tj
0 0 1 rg
-19.22996 0 Td
(http://creativecommons.org/licenses/by/4.0/)Tj
0 g
0 1 TD
(Commons License \(Attribution 4.0 International\), as described at )Tj
19.39596 1.00001 Td
(, is available under a Creative)Tj
/T1_1 1 Tf
-8.39198 0 Td
(Genome Research)Tj
/T1_0 1 Tf
-11.00398 0 Td
(This article, published in )Tj
ET
BT
/T1_2 1 Tf
11 0 0 11 120.86185 384.99997 Tm
(Service)Tj
-3.16599 1 Td
(Email Alerting)Tj
ET
BT
/T1_0 1 Tf
10 0 0 10 177 376.99994 Tm
(\240 )Tj
19.06496 1 Td
( )Tj
0 0 1 rg
/T1_2 1 Tf
-4.892 0 Td
(click here.)Tj
0 g
/T1_0 1 Tf
-14.17296 0 Td
(top right corner of the article or )Tj
0 1.00001 TD
(Receive free email alerts when new articles cite this article - sign up \
in the box at the)Tj
ET
72 364 m
556 364 l
0 0 m
S
BT
ET
q
468 0 0 60 80 161 cm
-1.00001 TL /Im1 Do
Q
72 121 m
556 121 l
0 0 m
S
BT
ET
BT
/T1_2 1 Tf
10 0 0 10 259.80881 85.99997 Tm
( )Tj
0 0 1 rg
-18.78088 0 Td
(https://genome.cshlp.org/subscriptions)Tj
0 g
/T1_0 1 Tf
9 0 0 9 214.05565 96 Tm
(go to: )Tj
/T1_1 1 Tf
-8.66998 0 Td
(Genome Research )Tj
/T1_0 1 Tf
-7.11398 0 Td
(To subscribe to )Tj
ET
72 70 m
556 70 l
0 0 m
S
BT
ET
BT
/T1_0 1 Tf
10 0 0 10 74 44 Tm
(\251 2017 Koren et al.; Published by Cold Spring Harbor Laboratory Press\
)Tj
ET
BT
/T1_0 1 Tf
8 0 0 8 505.41565 779 Tm
( )Tj
0 0 1 rg
-16.44997 0 Td
(Cold Spring Harbor Laboratory Press)Tj
0 g
-17.34198 0 Td
( on November 29, 2024 - Published by )Tj
0 0 1 rg
-7.94798 0 Td
(genome.cshlp.org)Tj
0 g
-8.11398 0 Td
(Downloaded from )Tj
ET
endstream
endobj
306 0 obj
<>/Filter/FlateDecode/Height 300/Length 43522/Name/X/Subtype/Image/Type/XObject/Width 1200>>stream
H‰ì×OH›yÀñ„
6± ¬Ðd,ô ö(lA}çГ5=ô²bÊàE1eñ a&,LõYÖ€¤4¥^dh‚séa¢ždé«Â„¾:…íÐn²à‚0IpÀ¥ûTÁíÚ“ø{ß7¾ÊË[Íûüž¼ž¾ïß¿? ¨?ïéA ¨Kô Ô'z ê= õ‰ DÞÜÞÏfå&³¶qôÃߌõâ'\Ð:ÜîÃû¦«rïúp£]=¼ €rô €’ìgsysë¹ýŸ\î0÷2¥D_y$ %åæ¢Þ%×æîN)Ç&Ãês j= °¼¹ýÎÜÊoÉu[JPzÐéþ§Ñë9ïõH$ž÷\º ]¥ JBøTÆXϬmüf¬WZ žJ’ðC^•kG³Þåô: p(onK î.H:½‹2’„°»K:±Ñëqz €ÊBuN2p'±¸›\ÙK¥ÞÅZÒƒ’‡ÍÝ-¾›
n—Óë 8êSýdàg5iõ®–Þ)D§w p=Ô•ýln'¾(%(=èô.¡ÁíjñÝ<C¹wz [у@ L?ž—tz‘ÊÕâë‘0”<$ @ š·›\‘ÌëN/R$% °Çé] ¬E5l'¾ø6:»—J;½HUjôzZý}èÿ“Ü8½ €%èA &9X‚MZGƒÛ}Qï’ûæîN¹ž÷zNM*Yõ÷ƒm?ܤÿ%Wù—7·ö³9v.¬Å×ÓÚß'W§ PŒjLÆX•«m'J ^ЮJúÉUîÕ—”*̬m¼3·òæ¶#…{H’¶-8Úâ»Ùàv9µ €Zô P3¤•^‡§v“+6œ%M$e$
hsÉw”ÔÝ]Z‘«¤¢mç‘/ë ]¤
@
Úð6:›Ž=±:‘½ž_Ok_“ÖaéAÅò•0ÜM.Û†ƒí‘)y6Ÿ =T»¼¹ýKhB®–žÒêïkéí©ÌÚ‰/î$~ÊëvzmáI³Þeç‰ Êу@U{}3=cÝü·Ëº4<(7Ö¢Ä^*-oCÚІ³š´ŽëÏì8 ÀRô P¥òæö/¡ ¹Z4¿ÑëiŽ¶úû,šo©Â'~z3=cé)í‘U÷f >EÕh'¾ø:<µŸÍY1¼JKðcR…o£³ò–¬.ï§suÙŠÉ 6£ªó*ôE¥ÓàvyC—†åÆŠù6Ë›ÛÿOeŒuµc/µGÕÎ p=T‘ýlns`P2ÇŠá-¾ž+“^ÔŽÍ¿ÎÈ«S5°su¹öÞ ¨Oô P-$%vÍ‘·«=2%=¨|r…ØK¥Í‘1yg%oI››9û €J@U!c¬KÑXƒ8ƒ’„Ê'Wš×á©tlþŒC$å)Ù Àqô Pùv⋯Bß)+
Øó•O®X»É•W¡‰ýl®¼Ç½žÎÕeµ+ 8ˆ*œE1(i£ÍÍ4iÊ'W¸¼¹½90X^zƒW&'”¯ àz¨dÅ`³Þ%1Øàv)Ÿ\$% %K}ðú³Å&Ê• AÚ&•Jϵµ5ó¥)ŽýVÓ4ïÞîînß-Ÿ×ëudCT‹b°Õß×y |lu)# ½žÎÕeëV °=hƒøÓx"ž0£ÈÏK†%Ýn·¥‹¡’YƒžÀà•É åc«Q©IÈ« µ‡´””`t:šJ¥ÊxVbPª0p7 ¤
Õ¨÷ÀÙÇÂ")¿Ý§|l{äA«_ýØêUR^¶Ø¤uX½ €èA‹˜¦þ>|¬ÂÊ Õ6yoÒwËWêƒÙl6ùsrmmÍxnœ¤º®÷úze8mXQ$O$R$UÔŽ%?KÞóÆžSßv£×Ó¹ºlÏJ ¶¡?%'
•N§Sÿü¿Œò~áõx<úWº¦in·»À„Ø£Xø~XáJ’l‘"…="˜H$äZü|ÿp