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Tretoquinol
Names
Preferred IUPAC name
(1S )-1-[(3,4,5-Trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol
Identifiers
ChEMBL
ChemSpider
MeSH
Tretoquinol
UNII
InChI=1S/C19H23NO5/c1-23-17-7-11(8-18(24-2)19(17)25-3)6-14-13-10-16(22)15(21)9-12(13)4-5-20-14/h7-10,14,20-22H,4-6H2,1-3H3/t14-/m0/s1
Y Key: RGVPOXRFEPSFGH-AWEZNQCLSA-N
Y InChI=1/C19H23NO5/c1-23-17-7-11(8-18(24-2)19(17)25-3)6-14-13-10-16(22)15(21)9-12(13)4-5-20-14/h7-10,14,20-22H,4-6H2,1-3H3/t14-/m0/s1
Key: RGVPOXRFEPSFGH-AWEZNQCLBM
O(c1cc(cc(OC)c1OC)C[C@H]3c2c(cc(O)c(O)c2)CCN3)C
Properties
C19 H23 NO5
Molar mass
345.39 g/mol
Pharmacology
R03AC09 (WHO )
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Tretoquinol is a beta-adrenergic agonist .[ 1] [ 2]
References
^ Yamato, E.; Hirakura, M.; Sugasawa, S. (1966). "Synthesis of 6,7-dihydrox-1,2,3,4-tetrahydroisoquinoline derivatives". Tetrahedron . 22 : 129–134. doi :10.1016/S0040-4020(01)82177-3 .
^ Konkar, A. A.; Vansal, S. S.; Shams, G.; Fraundorfer, P. F.; Zheng, W. P.; Nikulin, V. I.; De Los Angeles, J.; Fertel, R. H.; Miller, D. D.; Feller, D. R. (1999-11-01). "β-Adrenoceptor Subtype Activities of Trimetoquinol Derivatives: Biochemical Studies on Human β-Adrenoceptors Expressed in Chinese Hamster Ovary Cells" . The Journal of Pharmacology and Experimental Therapeutics . 291 (2). Jpet.aspetjournals.org: 875–883. PMID 10525112 . Retrieved 2012-08-20 .
α1
Agonists Antagonists
Abanoquil
Ajmalicine
Alfuzosin
Anisodamine
Anisodine
Atiprosin
Atypical antipsychotics (e.g., brexpiprazole , clozapine , olanzapine , quetiapine , risperidone )
Benoxathian
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Buflomedil
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Etoperidone
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L-765,314
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Pardoprunox
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Urapidil
WB-4101
Zolertine
α2
Agonists Antagonists
1-PP
Adimolol
Amesergide
Aptazapine
Atipamezole
Atypical antipsychotics (e.g., asenapine , brexpiprazole , clozapine , lurasidone , olanzapine , paliperidone , quetiapine , risperidone , zotepine )
Azapirones (e.g., buspirone , gepirone , ipsapirone , tandospirone )
BRL-44408
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NAN-190
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Setiptiline
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Sunepitron
Terguride
Tolazoline
Typical antipsychotics (e.g., chlorpromazine , fluphenazine , loxapine , thioridazine )
Yohimbine
β