AS-19 (drug)

AS-19
Identifiers
	IUPAC name (2S)-N,N-dimethyl-5-(1,3,5-trimethylpyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine;
CAS Number	1000578-26-6 ;
PubChem CID	23642275;
ChemSpider	24605931 ;
UNII	LA5AQ5R6QS;
ChEMBL	ChEMBL2164327;
Chemical and physical data
Formula	C18H25N3
Molar mass	283.419 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C(=NN1C)C)C2=C3CC[C@@H](CC3=CC=C2)N(C)C;
	InChI InChI=1S/C18H25N3/c1-12-18(13(2)21(5)19-12)17-8-6-7-14-11-15(20(3)4)9-10-16(14)17/h6-8,15H,9-11H2,1-5H3/t15-/m0/s1 ; Key:BTTOYOKCLDAHHO-HNNXBMFYSA-N ;
	(verify)

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AS-19 is a substance which acts as a potent agonist at the 5-HT₇ receptor, with an IC₅₀ of 0.83 nM. It reverses the amnesia induced by drugs such as scopolamine and dizocilpine and improves long-term memory acquisition, but inhibits short-term memory formation.^[1]^[2]

References

^ Meneses A, Perez-Garcia G, Liy-Salmeron G, Flores-Galvez D, Castillo C, Castillo E (December 2008). "The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation". Behavioural Brain Research. 195 (1): 112–9. doi:10.1016/j.bbr.2007.11.023. PMID 18191236. S2CID 144901859.
^ Perez-García G, Meneses A (December 2008). "Ex vivo study of 5-HT(1A) and 5-HT(7) receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia". Behavioural Brain Research. 195 (1): 139–46. doi:10.1016/j.bbr.2008.07.033. PMID 18723050. S2CID 140204255.

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[1] Meneses A, Perez-Garcia G, Liy-Salmeron G, Flores-Galvez D, Castillo C, Castillo E (December 2008). "The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation". Behavioural Brain Research. 195 (1): 112–9. doi:10.1016/j.bbr.2007.11.023. PMID 18191236. S2CID 144901859.

[2] Perez-García G, Meneses A (December 2008). "Ex vivo study of 5-HT(1A) and 5-HT(7) receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia". Behavioural Brain Research. 195 (1): 139–46. doi:10.1016/j.bbr.2008.07.033. PMID 18723050. S2CID 140204255.

[1]

[2]

See also

References