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HLA Correlations with Clinical Phenotypes and Risk of Metabolic Comorbidities in Singapore Chinese Psoriasis Patients

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Abstract

Introduction

Psoriasis is a systemic, chronic inflammatory disease that not only afflicts the skin but is also associated with cardiovascular disease and metabolic syndrome. The strongest susceptibility loci for the disease is within the human leukocyte antigen (HLA) complex, though specific HLA allelic associations vary between populations.

Objective

Our objective was to investigate HLA associations with clinical phenotypes of psoriasis and metabolic syndrome in Chinese psoriasis cases.

Methods

We conducted an observational case–control study in Singapore with a cohort of psoriasis cases consecutively recruited from an outpatient specialist dermatological center (n = 120) compared with 130 healthy controls.

Results

Significant HLA associations with psoriasis were observed with HLA-A*02:07, B*46:01, C*01:02, and C*06:02. The three-locus haplotype of A*02:07-C*01:02-B*46:01 was also significant (odds ratio [OR] 3.07; p = 9.47 × 10−5). We also observed an association between nail psoriasis and HLA-A*02:07 carriers (OR 4.50; p = 0.002), whereas C*06:02 carriers were less prone to have nail involvement (OR 0.16; p = 0.004). HLA-A*02:07 was also identified as a possible risk allele for hypertension (OR 2.90; p < 0.05), and C*01:02 was a possible risk allele for dyslipidemia (OR 3.36; p < 0.05), both known to be common comorbidities in patients with psoriasis.

Conclusion

Our results demonstrate the growing importance of discerning population-specific clinical phenotypes and their association with certain HLA alleles in psoriasis.

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Acknowledgements

The authors are grateful for the support of research coordinators from the National Skin Centre: Jie Si Kwa, Yan Qin Mak, Umairah Adnan, Joan Fung and Veron Lu.

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Author notes

  1. Hazel H. Oon, Ee Chee Ren are share senior authorship.

Authors and Affiliations

  1. Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, #03-06, Immunos Building, Singapore, 138648, Singapore

    Meixin Shen & Ee Chee Ren

  2. John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA

    Soon Wei Daniel Lim

  3. National Skin Centre (S) Pte Ltd, 1 Mandalay Rd, Singapore, 308205, Singapore

    Eugene S. Tan & Hazel H. Oon

  4. Department of Microbiology and Immunology, National University of Singapore, 5 Science Drive 2, MD4, Level 3, Singapore, 117545, Singapore

    Ee Chee Ren

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  1. Meixin Shen
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  2. Soon Wei Daniel Lim
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  3. Eugene S. Tan
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  4. Hazel H. Oon
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Corresponding authors

Correspondence to Hazel H. Oon or Ee Chee Ren.

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Conflict of interest

MS, SWDL, EST, HHO, and ECR have no conflicts of interest that are directly relevant to the content of this article.

Funding

This study was funded by Singapore Immunology Network F00006 core fund.

Ethical approval and informed consent

This clinical study was approved by the IRB on “Genetic susceptibility in psoriasis with psoriatic arthritis and metabolic syndrome” (IRB number 2014/01132) and conducted according to the principles of the Declaration of Helsinki.

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Shen, M., Lim, S.W.D., Tan, E.S. et al. HLA Correlations with Clinical Phenotypes and Risk of Metabolic Comorbidities in Singapore Chinese Psoriasis Patients. Mol Diagn Ther 23, 751–760 (2019). https://doi.org/10.1007/s40291-019-00423-z

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  • DOI: https://doi.org/10.1007/s40291-019-00423-z

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