Rams v 49ers Prediction, Picks & Best Bets for Thursday Night Football

Last Updated on Wed Dec 11 2024
Reviewed By: Mike McKean
Rams v 49ers Prediction, Picks & Best Bets for Thursday Night Football
Credit: Jayne Kamin - Oncea-Imagn Images
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To start Week 15 of the NFL season, the Los Angeles Rams will be on the road to take on the San Francisco 49ers.

Both teams are coming off wins, with the 49ers beating the Chicago Bears 38-13 and the Rams edging out the Buffalo Bills 44-42.

The Rams are now 6-7 against the spread and 7-6 on the season, while the 49ers are 6-7 on the season and 5-8 against the spread. The 49ers are 2.5-point favorites.

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Rams vs. 49ers Betting Preview: NFL Week 15

Game Details

  • Teams: Los Angeles Rams vs. San Francisco 49ers
  • Date: Thursday, Dec. 12, 2024
  • Kickoff: 8:15 pm ET
  • Location: Levi Stadium in Santa Clara, California

Latest Odds

  • Spread: Rams +2.5 (-110), 49ers -2.5 (-110)
  • Moneyline: Rams +120, 49ers -140
  • Total: Over/Under 48.5 (-110/-110)

Rams vs. 49ers Best Bet

The 49ers bounced back in a big way in Week 14, scoring 38 in their win over the Bears. Now, at home, they’ll face a Rams team they lost by three to earlier this season.

It’s been a rollercoaster this season for the 49ers. They’ve lost several players due to injury, including wide receiver Brandon Aiyuk and, more recently, both of their top running backs, Christian McCaffrey and Jordan Mason. Then, in Week 14, Isaac Guerendo left early with a foot injury. It sounds like he’ll play, but you have to wonder how effective he’ll be.

As for the Rams, their offense was cooking in Week 14, putting up 44 at home against the Bills. Wide receiver Puka Nacua led the way with 12 catches, well over 150 yards, and a score.  Running back Kyren Williams, despite his inefficiencies, had two touchdowns.

The problem for the Rams has been their pass defense, and more specficaly, the number of passing touchdowns they allow per game. They allow 1.77 per game, which is third-most in the NFL. Besides the Bills last week, though, they’ve been better, allowing one or less in four of seven games since Week 5.

In that same span, they’ve only allowed three rushing touchdowns to opposing running backs, and those were all against Saquon Barkley, who went nuclear on them for over 250 yards and three touchdowns.

The 49ers, though, allow more than one rushing touchdown per game. Williams hasn’t been efficient, but he has 12 rushing scores this season.

I’m expecting a lower-scoring game than earlier this season, and with the injuries the 49ers have had to deal with, I’ll lean toward the Rams. That said, hold off a bit longer to see if this gets out to three points. When that happens, pounce. If it doesn’t, I’m OK with 2.5.

Best Bet: Rams +2.5 (-110) at BetMGM Sportsbook

Score Prediction for Rams vs. 49ers

As mentioned, I think we may see a lower-scoring game. The 49ers have injuries in the running game, which could help the Rams slow down the passing game production.

As for the Rams offense, they’ll face a 49ers defense that’s allowed just four touchdowns over the last five games to opposing wide receivers.

I expect a lower-scoring game than the 27-24 Rams win earlier this season.

I’ll take the Rams 20-17.

NFL Player Props for Thursday Night Football

While betting who you think will win and by how much offers excitement, betting on individual player’s performance, like anytime or first scorer touchdown-related props, brings somewhat of a fantasy football-like element into it, especially when using the best sportsbooks to get top prices.

Looking at anytime touchdown props, my favorite of the night is the player most likely to score, and that’s Williams. He doesn’t run with a high yards-per-carry average but scores a bunch. He has 12 touchdowns this year, and the 49ers allow more than one rushing touchdown per game to opposing running backs.

Anytime TD Prediction & Probabilities

Los Angeles Rams

  • Kyren Williams Any Time TD: 63.64% (-175)
  • Puka Nacua Any Time TD: 47.62% (+110)
  • Cooper Kupp Any Time TD: 41.67% (+140)
  • Demarcus Robinson Any Time TD: 22.22% (+350)
  • Tyler Higbee Any Time TD: 20.00% (+400)

San Francisco 49ers

  • Isaac Guerendo Any Time TD: 60.00% (-150)
  • Patrick Taylor Any Time TD: 53.49% (-115)
  • George Kittle Any Time TD: 39.22% (+155)
  • Deebo Samuel Any Time TD: 38.46% (+160)
  • Jauan Jennings Any Time TD: 35.71% (+180)

First Scorer TD Prediction & Probabilities

Los Angeles Rams

  • Kyren Williams First TD Scorer: 16.67% (+500)
  • Puka Nacua First TD Scorer: 10.00% (+900)
  • Cooper Kupp First TD Scorer: 9.09% (+1000)
  • Demarcus Robinson First TD Scorer: 4.35% (+2200)
  • Blake Corum First TD Scorer: 4.35% (+2200)

San Francisco 49ers

  • Isaac Guerendo First TD Scorer: 16.67% (+500)
  • Patrick Taylor First TD Scorer: 15.38% (+550)
  • Deebo Samuel First TD Scorer: 10.00% (+900)
  • George Kittle First TD Scorer: 9.09% (+1000)
  • Jauan Jennings First TD Scorer: 8.33% (+1100) ​
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