BMPR1A Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB
3QB4 , 1ES7 , 1REW , 2GOO , 2H62 , 2H64 , 2K3G , 2QJ9 , 2QJA , 2QJB , 3NH7
Dynodwyr Cyfenwau BMPR1A Dynodwyr allanol OMIM: 601299 HomoloGene: 20911 GeneCards: BMPR1A Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • protein homodimerization activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • transmembrane receptor protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • SMAD binding • ATP binding • BMP receptor activity • transforming growth factor beta-activated receptor activity • transforming growth factor beta receptor activity, type I • growth factor binding Cydrannau o'r gell • integral component of membrane • HFE-transferrin receptor complex • bilen • Cellbilen • soma • dendrite • caveola • external side of plasma membrane • integral component of plasma membrane • receptor complex • cell surface Prosesau biolegol • somitogenesis • pattern specification process • roof of mouth development • cell differentiation • pituitary gland development • endoderm development • chondrocyte differentiation • neural crest cell development • lateral mesoderm development • lung development • positive regulation of bone mineralization • embryonic organ development • paraxial mesoderm structural organization • positive regulation of epithelial cell proliferation • phosphorylation • negative regulation of neurogenesis • positive regulation of pathway-restricted SMAD protein phosphorylation • mesoderm formation • ectoderm development • embryonic digit morphogenesis • heart morphogenesis • cellular response to BMP stimulus • in utero embryonic development • BMP signaling pathway • hindlimb morphogenesis • nervous system development • dorsal/ventral axis specification • regulation of lateral mesodermal cell fate specification • stem cell population maintenance • odontogenesis of dentin-containing tooth • Mullerian duct regression • endocardial cushion formation • protein phosphorylation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • heart development • cartilage development • positive regulation of osteoblast differentiation • developmental growth • transmembrane receptor protein serine/threonine kinase signaling pathway • positive regulation of mesenchymal cell proliferation • heart formation • neural plate pattern specification • embryonic morphogenesis • mesendoderm development • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • regulation of cellular senescence • neural plate mediolateral regionalization • dorsal/ventral pattern formation • transforming growth factor beta receptor signaling pathway • positive regulation of SMAD protein signal transduction • anterior/posterior pattern specification • paraxial mesoderm development • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of smooth muscle cell migration • BMP signaling pathway involved in heart development • regulation of cardiac muscle cell apoptotic process • outflow tract septum morphogenesis • outflow tract morphogenesis • cardiac conduction system development • mitral valve morphogenesis • tricuspid valve morphogenesis • endocardial cushion morphogenesis • cardiac right ventricle morphogenesis • ventricular trabecula myocardium morphogenesis • ventricular compact myocardium morphogenesis • dorsal aorta morphogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of cardiac muscle cell proliferation • positive regulation of cardiac muscle cell proliferation • pharyngeal arch artery morphogenesis • positive regulation of cardiac ventricle development • positive regulation of vascular associated smooth muscle cell proliferation • fibrous ring of heart morphogenesis • regulation of neural crest cell differentiation Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[ 1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn BMPR1A yw BMPR1A a elwir hefyd yn Bone morphogenetic protein receptor type 1A (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q23.2.[ 2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BMPR1A.
ALK3
SKR5
CD292
ACVRLK3
10q23del
"Enrichment of Adipose-Derived Stromal Cells for BMPR1A Facilitates Enhanced Adipogenesis. ". Tissue Eng Part A . 2016. PMID 26585335 . "Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis. ". Oncotarget . 2015. PMID 26274893 . "Identification of coding exon 3 duplication in the BMPR1A gene in a patient with juvenile polyposis syndrome. ". Jpn J Clin Oncol . 2014. PMID 25129392 . "Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis. ". Br J Cancer . 2013. PMID 23969729 . "Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines. ". PLoS One . 2013. PMID 23593444 . 
