Welcome to our March research update! Getting involved with research is an important way to impact asthma and allergy treatments, education, and awareness.
This month, we are highlighting clinical trials, surveys, and news on:
- Black teens with asthma
- Eosinophilic asthma
- Nasal polyps clinical trial and survey
- Respiratory syncytial virus (RSV)
- Dust mite allergy treatment
- Chronic hives
- Eczema
Note: The links below will take you to external websites.
Clinical Trials
Research Study for Black Teens with Asthma
KDH Research & Communication (KDHRC), a research organization in Atlanta, Georgia, is seeking input on the Personalized Approach To Habits – Sleep (PATH-S) app prototype. PATH-S will use casual gaming and intermittent reinforcement techniques to encourage teens to adopt and persist with personalized habits to improve sleep.
After a 90-minute Zoom interview, teens will receive a $100 incentive for participating. If you have any questions, please contact Morgan Fleming at [email protected]. If you are interested in participating, then sign up by visiting this link.
Sponsored by KDH Research & Communication
Eosinophilic Asthma Research Study Enrolling Adults and Children
We are seeking volunteers for a paid research study that seeks to improve the way we treat severe asthma. This new study seeks to evaluate the safety of the investigational drug dexpramipexole (also called “Dex”) and how well it works for the treatment of this chronic condition.
Qualified participants must:
- Be 12 years and up
- Have a physician diagnosis of asthma at least a year ago
- Must be taking at least one medium to high dose maintenance inhaler daily, with another asthma medication
- Have had at least 2 asthma exacerbations requiring treatment with steroids in the past year
Participants will be compensated for time and travel for visits, and study-related doctor’s visits and study assessments are at no cost to you.
Discover new ways to breathe easier and live better.
Sponsored by Science37
Would You Like to Participant in a Nasal Polyp Clinical Study?
Have you been diagnosed with chronic rhinosinusitis with nasal polyps (CRSwNP) and your symptoms not well controlled with standard available treatments? If so, this clinical study may be looking for participants like you.
This clinical study is called Duet ACT18207. It is being done to test an investigational study drug, lunsekimig, to see if it is safe and effective as a treatment for CRSwNP. This is an injectable solution and patients who enroll will either receive lunsekimig or placebo injections every 4 weeks during the 6 months of the study treatment period.
Sponsored by Sanofi
Runny Nose, Cough, Congestion, Wheezing?
Learn about a clinical trial for RSV.
RSV can be a serious, life-threatening virus for high-risk adults who are 18 years or older and meet at least 1 of the following criteria:
- Moderate or severe COPD
- Asthma
- Chronic lung disease
- Chronic cardiovascular disease
- ≥60 years of age (vaccinated or nonvaccinated)
Why join an RSV clinical trial?
- Access to an investigational oral medication for RSV
- Limited treatment options for high-risk adults
- No FDA-approved oral treatment available
- Don’t have to discontinue current medications to participate.
It’s important to get your RSV status confirmed quickly. To be eligible for the study, you must be diagnosed with RSV and enrolled within 3 days of your symptoms starting.
Sponsored by Gilead
Surveys
Nasal Polyps Research Opportunity
Exafield US, specialists in recruiting patients for scientific studies, are currently looking for people with chronic rhinosinusitis with nasal polyps.
The purpose of this study is to understand patient experiences of Chronic Rhinosinusitis with nasal polyps and how it affects their everyday lives on a day-to-day basis. The study does not involve treatments; we are only interested in opinions.
Participants would participate in a 30-minute survey (no phones or tablets) and will be paid for their time. Confirmation of diagnosis will be required to confirm eligibility.
If you or a loved one has been diagnosed with chronic rhinosinusitis with nasal polyps and are interested in participating or would like more information about the study, please contact Britney at: [email protected].
Sponsored by Exafield
Latest Asthma and Allergy News
Allergies
FDA Expands Label for Odactra Dust Mite Allergy Treatment to Children 5 to 11 Years Old
The Food and Drug Administration (FDA) has approved the use of Odactra for children ages 5 to 11. Odactra is a tablet for house dust mite allergies that dissolves under the tongue. This treatment can reduce allergy symptoms like sneezing, stuffy nose, and watery eyes.
The approval is based on the results of a large clinical trial of more than 1,400 children. The trial showed Odactra improved allergy symptoms by 22% compared to a placebo (non-treatment). The study also found that Odactra may help with asthma symptoms.
Most side effects were mild or moderate, like itchy mouth or stomach pain. There were no serious reactions that needed emergency treatment. This approval gives children, caregivers, and health care providers a possible new option for managing childhood dust mite allergies.
Chronic Hives
Real-World Experience of People Living with Chronic Hives
A recent study reveals that people with chronic spontaneous urticaria (CSU), also called chronic hives, often face large challenges. The study surveyed nearly 600 adults living with CSU to understand their experiences and challenges.
Most people faced a 2-year delay in diagnosis. They saw about 6 doctors for CSU care. Despite many (79%) using antihistamines for treatment, most (84%) still struggled with poorly controlled symptoms. Respondents with poorly controlled symptoms had worse quality of life compared to people with controlled symptoms. Mental, emotional, and social health were most impacted by poorly controlled symptoms.
Over half reported angioedema (swelling episodes), with an average of nearly 8 episodes per year. Common symptoms during flare-ups included sleep problems (62%), pain (55%), and fatigue (49%). The researchers highlighted the need for early diagnosis and personalized care to improve symptom control and overall well-being.
Eczema
New Results for a Potential Treatment for Moderate to Severe Eczema
Amgen and Kyowa Kirin announced positive results from trials testing rocatinlimab, a potential new treatment for moderate to severe atopic dermatitis (AD), also called eczema.
In 1 study, rocatinlimab improved AD symptoms compared to a placebo (non-treatment). After 24 weeks, 42.3% of people on the higher dose and 36.3% on the lower dose saw a 75% reduction in eczema severity. Rocatinlimab also improved skin clarity scores.
Another study tested rocatinlimab with topical (placed on the skin) treatments. It showed similar positive results. Common side effects in these studies included fever, chills, and headaches, with rare cases of stomach ulcers. Future studies will look at long-term effects and use in teens. Researchers are hopeful this new treatment will help people who struggle to control their eczema symptoms with current options.
Nasal Polyps
Tezepelumab Reduces Severity of Nasal Polyps and the Need for Surgery
New research shows that tezepelumab can reduce nasal polyps in adults. In the WAYPOINT study, participants received either tezepelumab or a placebo (non-treatment) every 4 weeks for 1 year. People treated with tezepelumab showed major improvements in nasal polyp size, congestion, and other symptoms like loss of smell. Improvements were seen as early as 2 to 4 weeks.
By the end of the study, tezepelumab reduced the need for nasal polyp surgery or corticosteroids by 92% compared to the placebo. The treatment was well-tolerated, with no major differences in side effects between groups. These results suggest that tezepelumab could be an effective option for people with severe nasal polyps. This may reduce the need for future surgeries and long-term steroid use.
FDA Accepts Applications for Depemokimab in Asthma and Nasal Polyps
The Food and Drug Administration (FDA) is reviewing a treatment called depemokimab for 2 uses: as an add-on treatment for asthma in people 12 and older and for adults with nasal polyps.
Depemokimab is designed for people with type 2 inflammation. It is a condition linked to asthma attacks and severe nasal polyps symptoms. This antibody targets IL-5, a protein that drives this inflammation. In clinical trials, people who took depemokimab saw positive results with just 2 doses per year. This could improve treatment by reducing the need for frequent injections. Depemokimab is not yet approved for use in any country. The FDA's decision is expected by Dec. 16, 2025.
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