Results from the international collaborative systematic literature review informing the 2023 EULAR recommendations for the treatment of systemic sclerosisAlain Lescoat, Eugenia Bertoldo, Jelena Čolić, Tania Santiago, Yossra A Suliman, Jenny Emmel, Philip G Conaghan, Yannick Allanore, Francesco del Galdo
7 November 2024
Imaging mass cytometry-based characterisation of fibroblast subsets and their cellular niches in systemic sclerosisAleix Rius Rigau, Minrui Liang, Veda Devakumar, Ranjana Neelagar, Alexandru-Emil Matei, Andrea-Hermina Györfi, Christina Bergmann, Tim Filla, Vladyslav Fedorchenko, Georg Schett, Jörg H W Distler, Yi-Nan Li
23 October 2024
Stratification according to autoantibody status in systemic sclerosis reveals distinct molecular signaturesBénedicte Rouvière, Christelle Le Dantec, Eleonore Bettacchioli, Lorenzo Beretta, Nathan Foulquier, Celine Cao, Christophe Jamin, Jacques-Olivier Pers, Martin Kerick, Javier Martin, on behalf of PRECISESADS Clinical Consortium, on behalf of PRECISESADS Metabolomic Study Group, Marta Eugenia Alarcón-Riquelme, Claire de Moreuil, Divi CornecSee the full list of authors
22 October 2024
Racial variability in immune responses only partially explains differential systemic sclerosis disease severityKamini E Kuchinad, Ji Soo Kim, Adrianne Woods, Gwen Leatherman, Laura Gutierrez-Alamillo, Maureen D Mayes, Robyn Domsic, Paula S Ramos, Richard M Silver, John Varga, Lesley Ann Saketkoo, Suzanne Kafaja, Victoria K Shanmugan, Jessica Gordon, Lorinda ChungSee the full list of authors
17 July 2024
Single-cell transcriptomes and chromatin accessibility of endothelial cells unravel transcription factors associated with dysregulated angiogenesis in systemic sclerosisMengqi Huang, Tracy Tabib, Dinesh Khanna, Shervin Assassi, Robyn Domsic, Robert Lafyatis
16 May 2024
Human hypofunctional NCF1 variants promote pulmonary fibrosis in the bleomycin-induced mouse model and patients with systemic sclerosis via expansion of SPP1 monocytes-derived macrophagesXinran Yuan, Xiaodong Qin, Kenji Takemoto, Jian Zhao, Matthew Sanderson, Xue Xu, Yu Zhang, Kristi L Helke, Bethany Jacobs Wolf, Joel M Guthridge, Judith A James, Xiaodong Zhou, Shervin Assassi, Carol Feghali-Bostwick, Dandan WangSee the full list of authors
18 September 2024
Identification and validation of anti-protein arginine methyltransferase 5 (PRMT5) antibody as a novel biomarker for systemic sclerosis (SSc)Minrui Liang, Lingbiao Wang, Xiaolong Tian, Kun Wang, Xiaoyi Zhu, Linlin Huang, Qing Li, Wenjing Ye, Chen Chen, Haihua Yang, Wanqing Wu, Xiangjun Chen, Xiaoxia Zhu, Yu Xue, Weiguo WanSee the full list of authors
29 April 2024
Combined inhibition of IL-1, IL-33 and IL-36 signalling by targeting IL1RAP ameliorates skin and lung fibrosis in preclinical models of systemic sclerosisCaitríona Grönberg, Sara Rattik, Cuong Tran-Manh, Xiang Zhou, Aleix Rius Rigau, Yi-Nan Li, Andrea-Hermina Györfi, Nicholas Dickel, Meik Kunz, Alexander Kreuter, Emil-Alexandru Matei, Honglin Zhu, Petter Skoog, David Liberg, Jörg HW DistlerSee the full list of authors
9 April 2024
CD7 activation regulates cytotoxicity-driven pathology in systemic sclerosis, yielding a target for selective cell depletionTheodoros Ioannis Papadimitriou, Prashant Singh, Arjan van Caam, Birgitte Walgreen, Mark A J Gorris, Elly L Vitters, Iris L van Ingen, Marije I Koenders, Ruben L Smeets, Madelon Vonk, Jolanda M de Vries, Peter M van der Kraan, Ypke van Oosterhout, Martijn A Huynen, Hans J P M KoenenSee the full list of authors
18 December 2023
Single-cell analysis reveals key differences between early-stage and late-stage systemic sclerosis skin across autoantibody subgroupsKristina Elizabeth Neergaard Clark, Shiwen Xu, Moustafa Attah, Voon H Ong, Christopher Dominic Buckley, Christopher P Denton
14 August 2023