High incidence of Epstein-Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically ill patients with COVID-19

doi:10.1016/j.idnow.2021.01.005

Observational Study

. 2021 May;51(3):296-299.

doi: 10.1016/j.idnow.2021.01.005. Epub 2021 Jan 18.

High incidence of Epstein-Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically ill patients with COVID-19

A Simonnet¹, I Engelmann², A-S Moreau¹, B Garcia¹, S Six¹, A El Kalioubie¹, L Robriquet¹, D Hober², M Jourdain³

Affiliations

¹ Pôle de réanimation, CHU de Lille, 59000 Lille, France.
² Laboratoire de virologie ULR3610, université de Lille et CHU de Lille, 59000 Lille, France.
³ Pôle de réanimation, CHU de Lille, 59000 Lille, France. Electronic address: [email protected].

PMID: 33495765
PMCID: PMC7816954
DOI: 10.1016/j.idnow.2021.01.005

Observational Study

High incidence of Epstein-Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically ill patients with COVID-19

A Simonnet et al. Infect Dis Now. 2021 May.

. 2021 May;51(3):296-299.

doi: 10.1016/j.idnow.2021.01.005. Epub 2021 Jan 18.

Authors

A Simonnet¹, I Engelmann², A-S Moreau¹, B Garcia¹, S Six¹, A El Kalioubie¹, L Robriquet¹, D Hober², M Jourdain³

Affiliations

¹ Pôle de réanimation, CHU de Lille, 59000 Lille, France.
² Laboratoire de virologie ULR3610, université de Lille et CHU de Lille, 59000 Lille, France.
³ Pôle de réanimation, CHU de Lille, 59000 Lille, France. Electronic address: [email protected].

PMID: 33495765
PMCID: PMC7816954
DOI: 10.1016/j.idnow.2021.01.005

Abstract

Background: Systemic reactivation of herpesviruses may occur in intensive care unit (ICU) patients and is associated with morbidity and mortality. Data on severe Coronavirus disease-19 (COVID-19) and concomitant reactivation of herpesviruses are lacking.

Methods: We selected patients admitted to ICU for confirmed COVID-19 who underwent systematic testing for Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human-herpes virus-6 (HHV-6) DNAemia while in the ICU. We retrospectively analysed frequency, timing, duration and co-occurrence of viral DNAemia.

Results: Thirty-four patients were included. Viremia with EBV, CMV, and HHV-6 was detected in 28 (82%), 5 (15%), and 7 (22%) patients, respectively. EBV reactivation occurred early after ICU admission and was associated with longer ICU length-of-stay.

Conclusions: While in the ICU, critically ill patients with COVID-19 are prone to develop reactivations due to various types of herpesviruses.

Keywords: COVID-19; Cytomegalovirus; Epstein–Barr virus.

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References

1. Walton A.H., Muenzer J.T., Rasche D., Boomer J.S., Sato B., Brownstein B.H., et al. Reactivation of multiple viruses in patients with sepsis. PLoS ONE. 2014;9:e98819. doi: 10.1371/journal.pone.0098819. - DOI - PMC - PubMed
1. Libert N., Bigaillon C., Chargari C., Bensalah M., de Rudnicki S., Muller V., et al. Epstein–Barr virus reactivation in critically ill immunocompetent patients. Biomed J. 2015;38:70. doi: 10.4103/2319-4170.132905. - DOI - PubMed
1. Ong D.S.Y., Bonten M.J.M., Spitoni C., Verduyn Lunel F.M., Frencken J.F., Horn J., et al. Epidemiology of multiple herpes viremia in previously immunocompetent patients with septic shock. Clin Infect Dis. 2017;64:1204–1210. doi: 10.1093/cid/cix120. - DOI - PubMed
1. MIPrea group, REALISM group, Mallet F., Perret M., Tran T., Meunier B., et al. Early herpes and TTV DNAemia in septic shock patients: a pilot study. Intensive Care Med Exp. 2019:7. doi: 10.1186/s40635-019-0256-z. - DOI - PMC - PubMed
1. World Health Organisation . 2020. Clinical management of COVID-19.

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[1] Walton A.H., Muenzer J.T., Rasche D., Boomer J.S., Sato B., Brownstein B.H., et al. Reactivation of multiple viruses in patients with sepsis. PLoS ONE. 2014;9:e98819. doi: 10.1371/journal.pone.0098819. - DOI - PMC - PubMed

[2] Walton A.H., Muenzer J.T., Rasche D., Boomer J.S., Sato B., Brownstein B.H., et al. Reactivation of multiple viruses in patients with sepsis. PLoS ONE. 2014;9:e98819. doi: 10.1371/journal.pone.0098819. - DOI - PMC - PubMed

[3] Libert N., Bigaillon C., Chargari C., Bensalah M., de Rudnicki S., Muller V., et al. Epstein–Barr virus reactivation in critically ill immunocompetent patients. Biomed J. 2015;38:70. doi: 10.4103/2319-4170.132905. - DOI - PubMed

[4] Libert N., Bigaillon C., Chargari C., Bensalah M., de Rudnicki S., Muller V., et al. Epstein–Barr virus reactivation in critically ill immunocompetent patients. Biomed J. 2015;38:70. doi: 10.4103/2319-4170.132905. - DOI - PubMed

[5] Ong D.S.Y., Bonten M.J.M., Spitoni C., Verduyn Lunel F.M., Frencken J.F., Horn J., et al. Epidemiology of multiple herpes viremia in previously immunocompetent patients with septic shock. Clin Infect Dis. 2017;64:1204–1210. doi: 10.1093/cid/cix120. - DOI - PubMed

[6] Ong D.S.Y., Bonten M.J.M., Spitoni C., Verduyn Lunel F.M., Frencken J.F., Horn J., et al. Epidemiology of multiple herpes viremia in previously immunocompetent patients with septic shock. Clin Infect Dis. 2017;64:1204–1210. doi: 10.1093/cid/cix120. - DOI - PubMed

[7] MIPrea group, REALISM group, Mallet F., Perret M., Tran T., Meunier B., et al. Early herpes and TTV DNAemia in septic shock patients: a pilot study. Intensive Care Med Exp. 2019:7. doi: 10.1186/s40635-019-0256-z. - DOI - PMC - PubMed

[8] MIPrea group, REALISM group, Mallet F., Perret M., Tran T., Meunier B., et al. Early herpes and TTV DNAemia in septic shock patients: a pilot study. Intensive Care Med Exp. 2019:7. doi: 10.1186/s40635-019-0256-z. - DOI - PMC - PubMed

[9] World Health Organisation . 2020. Clinical management of COVID-19.

[10] World Health Organisation . 2020. Clinical management of COVID-19.

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High incidence of Epstein-Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically ill patients with COVID-19

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High incidence of Epstein-Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically ill patients with COVID-19

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