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. 2018 Jul 10:10:29.
doi: 10.1186/s13099-018-0258-5. eCollection 2018.

Identification of Schizosaccharomyces pombe in the guts of healthy individuals and patients with colorectal cancer: preliminary evidence from a gut microbiome secretome study

Siok-Fong Chin  1 , Putri Intan Hafizah Megat Mohd Azlan  1 , Luqman Mazlan  2 , Hui-Min Neoh  1
Affiliations

Identification of Schizosaccharomyces pombe in the guts of healthy individuals and patients with colorectal cancer: preliminary evidence from a gut microbiome secretome study

Siok-Fong Chin et al. Gut Pathog. .

Abstract

Over the years, genetic profiling of the gut microbiome of patients with colorectal cancer (CRC) using genome sequencing has suggested over-representation of several bacterial taxa. However, little is known about the protein or metabolite secretions from the microbiota that could lead to CRC pathology. Proteomic studies on the role of microbial secretome in CRC are relatively rare. Here, we report the identification of proteins from Schizosaccharomyces pombe found in the stool samples of both healthy individuals and patients with CRC. We found that distinctive sets of S. pombe proteins were present exclusively and in high intensities in each group. Our finding may trigger a new interest in the role of gut mycobiota in carcinogenesis.

Keywords: Colorectal cancer; Human gut; Microbiome; Schizosaccharomyces pombe; Secretome.

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Figures

Fig. 1
Fig. 1
Distribution of secretome proteins identified from S. pombe in the gut of patients with CRC and control individuals. a Heat-map analysis revealed individual variation in secreted proteins by S. pombe; b discriminant analysis showed that proteins from S. pombe were well-discriminated between the CRC and control groups; c different sets of proteins were identified from S. pombe during the late and early stages of CRC
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