[Pharmacological treatment of impulsivity and aggressive behavior]
- PMID: 19967201
- DOI: 10.1590/s1516-44462009000600004
[Pharmacological treatment of impulsivity and aggressive behavior]
Abstract
Impulsivity and aggressive behavior occur frequently in a variety of psychiatric disorders and neurological diseases. Two lines of treatment could be employed, the treatment of the disorder or disease in which these symptoms occur or the treatment of the impulsivity and aggressive behavior itself. This second approach considers that there are neurobiological similarities underlying these behaviors regardless of the 'primary' diagnoses with which they are associated. Imbalance between limbic bottom-up drives, exerted by structures like the amygdala, and prefrontal top-down control mechanisms could be the ultimate reason for an aggressive-impulsive behavior. The role of serotonin, noradrenaline and dopamine were comprehensively investigated with regards to impulsive and aggressive behavior and these neurochemical data were further integrated with the neuroanatomical model, providing the bases to the rational pharmacological approach of these behaviors.
Similar articles
-
Pharmacotherapy of impulsive aggression: a quality comparison of controlled studies.Int J Law Psychiatry. 2013 May-Aug;36(3-4):258-63. doi: 10.1016/j.ijlp.2013.04.017. Epub 2013 Apr 30. Int J Law Psychiatry. 2013. PMID: 23642319 Review.
-
Impulsive aggression, delay discounting, and adolescent suicide attempts: effects of current psychotropic medication use and family history of suicidal behavior.J Child Adolesc Psychopharmacol. 2015 Mar;25(2):114-23. doi: 10.1089/cap.2014.0042. Epub 2015 Mar 6. J Child Adolesc Psychopharmacol. 2015. PMID: 25745870 Free PMC article.
-
Pharmacological manipulation of aggressiveness and impulsiveness in healthy volunteers.Prog Neuropsychopharmacol Biol Psychiatry. 1992 Jan;16(1):1-7. doi: 10.1016/0278-5846(92)90002-v. Prog Neuropsychopharmacol Biol Psychiatry. 1992. PMID: 1557501 Review.
-
Divalproex sodium for impulsive aggressive behavior in patients with personality disorder.J Clin Psychiatry. 1998 Dec;59(12):676-80. doi: 10.4088/jcp.v59n1206. J Clin Psychiatry. 1998. PMID: 9921702 Clinical Trial.
-
Fluoxetine and impulsive aggressive behavior in personality-disordered subjects.Arch Gen Psychiatry. 1997 Dec;54(12):1081-8. doi: 10.1001/archpsyc.1997.01830240035005. Arch Gen Psychiatry. 1997. PMID: 9400343 Clinical Trial.
Cited by
-
Endoxifen in Treatment of Individuals with Borderline Personality Disorder with Predominant Impulsivity: A Case Series.Consort Psychiatr. 2023 Dec 22;4(4):66-73. doi: 10.17816/CP13622. Consort Psychiatr. 2023. PMID: 38618630 Free PMC article.
-
Levels of impulsivity in individuals with cannabis use disorder.Trends Psychiatry Psychother. 2022 Jul 14;44(suppl 1):e20210449. doi: 10.47626/2237-6089-2021-0449. Trends Psychiatry Psychother. 2022. PMID: 35500250 Free PMC article.
-
Amygdala and Hypothalamus: Historical Overview With Focus on Aggression.Neurosurgery. 2019 Jul 1;85(1):11-30. doi: 10.1093/neuros/nyy635. Neurosurgery. 2019. PMID: 30690521 Free PMC article.
-
Chronic Testosterone Increases Impulsivity and Influences the Transcriptional Activity of the Alpha-2A Adrenergic Receptor Signaling Pathway in Rat Brain.Mol Neurobiol. 2019 Jun;56(6):4061-4071. doi: 10.1007/s12035-018-1350-z. Epub 2018 Sep 27. Mol Neurobiol. 2019. PMID: 30264294 Free PMC article.
-
The efficacy of Ritalin in ADHD children under neurofeedback training.Neurol Sci. 2018 Dec;39(12):2071-2078. doi: 10.1007/s10072-018-3539-3. Epub 2018 Sep 5. Neurol Sci. 2018. PMID: 30187306 Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
