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Approaches for the development of future at-scale neuromorphic systems based on principles of biointelligence are described, along with potential applications of scalable neuromorphic architectures and the challenges that need to be overcome.
Cryo-electron microscopy structures of native type A GABA receptors from human brain reveal diverse subunit compositions, protein binding partners and binding sites for antiepileptic drugs.
Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.
Dopaminergic neurons in the ventral tegmental area have a role in modulating aggression in adult male mice, and this effect of dopamine depends strongly on fighting experience.
Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in the intestine and provides a conceptual framework for the study of tissue immune networks.
Whistler-mode chorus waves have been observed in the tail region of the terrestrial magnetosphere, where the magnetic field is not dipolar so that chorus waves were not expected, and their generation mechanisms have been tested with state-of-the-art observations.
Using whole-Earth oscillations to constrain a 3D global model of attenuation for the whole mantle, low attenuation correlates with low velocity in the lower mantle, suggesting long-lived deep-mantle provinces.
RELMβ mediates a gut immuneâepithelial circuit regulating tolerance to food antigens, offering targetable candidates for the prevention and treatment of food allergies.
A massively parallel assay developed to map the essential photosynthetic enzyme rubisco showed that non-trivial biochemical changes and improvements in CO2 affinity are possible, signposting further enzyme engineering efforts to increase crop yields.
A study reports optimized mitochondrial base editors with reduced off-target effects to facilitate the generation of mouse models of human mitochondrial diseases.
We developed PRINT, a computational method that identifies footprints of DNAâprotein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.