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Newest Articles
Morphoregulatory ADD3 underlies glioblastoma growth and formation of tumor–tumor connectionsMorphoregulatory ADD3 controls glioblastoma stem cell (GSC) connectivity, proliferation, and chemoresistance, showing that GSC morphology is a new layer of tumor heterogeneity.
- Correction: Microglia are essential for tissue contraction in wound closure after brain injury in zebrafish larvae
Although in humans, the brain fails to heal after an injury, young zebrafish are able to restore tissue structural integrity in less than 24 h, thanks to the mechanical action of microglia.
Unremodeled GPI-anchored proteins at the plasma membrane trigger aberrant endocytosisA unique plasma membrane stressor induces vacuolar degradation of abnormally endocytosed proteins.
Membrane transporters modulating the toxicity of arsenic, cadmium, and mercury in human cellsThis study employs CRISPR/Cas9 loss-of-function screens to simultaneously investigate the contribution of the entire transportome to regulating the toxicity of arsenic, cadmium, and mercury in human cell lines.
SPHK1/S1PR1/PPAR-α axis restores TJs between uroepithelium providing new ideas for IC/BPS treatmentThis study provides a novel therapeutic idea based on the poor limited efficacy of IC/BPS treatment options. Using urinary metabolite and tight junctions as therapeutic targets is revelatory.
Vascular dysfunction is at the onset of oxaliplatin-induced peripheral neuropathy symptoms in miceThis study identifies blood-nerve barrier and vascular contraction dysfunction in nerve blood vessels as contributors to oxaliplatin-induced peripheral neuropathy (OIPN), and demonstrates that vasodilators can alleviate neuropathic symptoms and nerve hypoxia, highlighting the importance of vascular health in OIPN management.
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About Life Science Alliance
Life Science Alliance is an international, open-access, editorially independent, and peer-reviewed journal launched by an alliance of three preeminent scientific organizations: EMBO, The Rockefeller University, and Cold Spring Harbor Laboratory. Life Science Alliance is committed to the rapid, fair, and transparent publication of research papers, resources, and new methods from the full spectrum of life science and biomedical research.
Life Science Alliance LLC is limited liability non-stock corporation jointly owned by Cold Spring Harbor Laboratory, EMBO Press Innovations gGmbH and The Rockefeller University and incorporated in the State of Delaware, USA, with company number 6706208.