%PDF-1.4 %âãÏÓ 238 0 obj <> endobj 237 0 obj <>stream Acrobat Distiller 11.0 (Windows) Arbortext Advanced Print Publisher 10.0.1465/W Unicode 2025-01-12T01:35:11-08:00 2019-08-28T08:18:22+05:30 2025-01-12T01:35:11-08:00 application/pdf <alt> <li xml:lang="x-default">Unique genetic basis of the distinct antibiotic potency of high acetic acid production in the probiotic yeast Saccharomyces cerevisiae var. boulardii</li> </alt> uuid:2e3d3121-1dd2-11b2-0a00-2a0a278d5b00 uuid:2e3d3124-1dd2-11b2-0a00-1e0000000000 endstream endobj 236 0 obj <> endobj 38 0 obj <> endobj 3 0 obj <> endobj 142 0 obj <> endobj 141 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Type/Page>> endobj 163 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Type/Page>> endobj 164 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Type/Page>> endobj 165 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Type/Page>> endobj 166 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Type/Page>> endobj 167 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Type/Page>> endobj 168 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Type/Page>> endobj 240 0 obj <>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>> endobj 267 0 obj [274 0 R 275 0 R 276 0 R 277 0 R 278 0 R 279 0 R 280 0 R 281 0 R 282 0 R] endobj 268 0 obj <>stream q 300 0 0 75 164 679 cm /Im0 Do Q BT /T1_0 1 Tf 10 0 0 10 344.36975 565.99979 Tm ( )Tj 0 0 1 rg -10.34099 0 Td (10.1101/gr.243147.118)Tj 0 g -16.89599 0 Td (Access the most recent version at doi:)Tj 6.447 1 Td (2019 29: 1478-1494 originally published online August 29, 2019)Tj /T1_1 1 Tf -6.447 0 Td (Genome Res.\240)Tj /T1_0 1 Tf 0 1.00001 TD (\240 )Tj 0 1 TD (Benjamin Offei, Paul Vandecruys, Stijn De Graeve, et al. )Tj T* (\240 )Tj /T1_2 1 Tf 15 0 0 15 183.75024 615.99994 Tm (boulardii)Tj /T1_3 1 Tf -2.33501 0 Td ( var. )Tj /T1_2 1 Tf -5.11501 0 Td (cerevisiae)Tj 21.50588 1 Td (Saccharomyces)Tj /T1_3 1 Tf -21.50588 0 Td (acetic acid production in the probiotic yeast )Tj T* (Unique genetic basis of the distinct antibiotic potency of high)Tj ET 72 554 m 556 554 l 0 0 m S BT ET BT /T1_0 1 Tf 11 0 0 11 156.942 508.99994 Tm (\240 )Tj /T1_3 1 Tf -3.50099 1 Td (Material)Tj -2.77799 1.00001 Td (Supplemental)Tj ET BT /T1_0 1 Tf 10 0 0 10 177 521.99997 Tm (\240 )Tj 32.62186 1 Td ( )Tj 0 0 1 rg /T1_3 1 Tf -32.62186 0 Td (http://genome.cshlp.org/content/suppl/2019/08/14/gr.243147.118.DC1)Tj ET BT 0 g /T1_0 1 Tf 11 0 0 11 156.942 477.99997 Tm (\240 )Tj /T1_3 1 Tf -5.11299 1 Td (References)Tj ET BT /T1_0 1 Tf 10 0 0 10 177 469.99994 Tm (\240 )Tj 28.67284 1 Td ( )Tj 0 0 1 rg /T1_3 1 Tf -28.67284 0 Td (http://genome.cshlp.org/content/29/9/1478.full.html#ref-list-1)Tj 0 g /T1_0 1 Tf 0 1.00001 TD (This article cites 101 articles, 18 of which can be accessed free at:)Tj ET BT /T1_0 1 Tf 11 0 0 11 156.942 447.99997 Tm (\240 )Tj /T1_3 1 Tf -6.05798 1 Td (Open Access)Tj ET BT /T1_0 1 Tf 10 0 0 10 177 449.99997 Tm (\240 )Tj 23.95496 1 Td ( Open Access option.)Tj /T1_1 1 Tf -8.39198 0 Td (Genome Research)Tj /T1_0 1 Tf -15.56298 0 Td (Freely available online through the )Tj ET BT /T1_0 1 Tf 11 0 0 11 164.94208 399.99991 Tm (\240 )Tj /T1_3 1 Tf -3.44598 1 Td (License)Tj -1.16501 1.00001 Td (Commons )Tj 0.94299 1 Td (Creative)Tj ET BT /T1_0 1 Tf 10 0 0 10 389.18954 413.99994 Tm (.)Tj 0 0 1 rg -20.61895 0 Td (http://creativecommons.org/licenses/by-nc/4.0/)Tj 0 g 0 1 TD (Commons License \(Attribution-NonCommercial 4.0 International\), as desc\ ribed at )Tj 19.39596 1.00001 Td (, is available under a Creative)Tj /T1_1 1 Tf -8.39198 0 Td (Genome Research)Tj /T1_0 1 Tf -11.00398 0 Td (This article, published in )Tj ET BT /T1_3 1 Tf 11 0 0 11 120.86185 369.99997 Tm (Service)Tj -3.16599 1 Td (Email Alerting)Tj ET BT /T1_0 1 Tf 10 0 0 10 177 361.99994 Tm (\240 )Tj 19.06496 1 Td ( )Tj 0 0 1 rg /T1_3 1 Tf -4.892 0 Td (click here.)Tj 0 g /T1_0 1 Tf -14.17296 0 Td (top right corner of the article or )Tj 0 1.00001 TD (Receive free email alerts when new articles cite this article - sign up \ in the box at the)Tj ET 72 349 m 556 349 l 0 0 m S BT ET q 468 0 0 60 80 161 cm -1.00001 TL /Im1 Do Q 72 121 m 556 121 l 0 0 m S BT ET BT /T1_3 1 Tf 10 0 0 10 259.80881 85.99997 Tm ( )Tj 0 0 1 rg -18.78088 0 Td (https://genome.cshlp.org/subscriptions)Tj 0 g /T1_0 1 Tf 9 0 0 9 214.05565 96 Tm (go to: )Tj /T1_1 1 Tf -8.66998 0 Td (Genome Research )Tj /T1_0 1 Tf -7.11398 0 Td (To subscribe to )Tj ET 72 70 m 556 70 l 0 0 m S BT ET BT /T1_0 1 Tf 10 0 0 10 74 44 Tm (\251 2019 Offei et al.; Published by Cold Spring Harbor Laboratory Press\ )Tj ET BT /T1_0 1 Tf 8 0 0 8 501.19568 779 Tm ( )Tj 0 0 1 rg -16.44997 0 Td (Cold Spring Harbor Laboratory Press)Tj 0 g -16.28698 0 Td ( on January 12, 2025 - Published by )Tj 0 0 1 rg -7.94799 0 Td (genome.cshlp.org)Tj 0 g -8.11398 0 Td (Downloaded from )Tj ET endstream endobj 272 0 obj <>/Filter/FlateDecode/Height 300/Length 43522/Name/X/Subtype/Image/Type/XObject/Width 1200>>stream H‰ì×OH›yÀñ„ 6± ¬Ðd,ô ö(lA}çГ5=ô²bÊàE1eñ a&,LõYÖ€¤4¥^dh‚séa¢ždé«Â„¾:…íÐn²à‚0IpÀ¥ûTÁíÚ“ø{ß7¾ÊË[Íûüž¼ž¾ïß¿? 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