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ENZYME

ENZYME entry: EC 2.3.2.2

Accepted Name
gamma-glutamyltransferase
Alternative Name(s)
gamma-glutamyltranspeptidase
gamma-glutamyl transpeptidase
glutamyl transpeptidase
Reaction catalysed
an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]
Comment(s)
  • The mammlian enzyme is part of the cell antioxidant defense mechanism.
  • It initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH levels.
  • The protein also has EC 3.4.19.13 activity.
  • The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide.
  • The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions.
Cross-references
BRENDA2.3.2.2
EC2PDB2.3.2.2
ExplorEnz2.3.2.2
PRIAM enzyme-specific profiles2.3.2.2
KEGG Ligand Database for Enzyme Nomenclature2.3.2.2
IUBMB Enzyme Nomenclature2.3.2.2
IntEnz2.3.2.2
MEDLINEFind literature relating to 2.3.2.2
MetaCyc2.3.2.2
Rhea expert-curated reactions2.3.2.2
UniProtKB/Swiss-Prot
Q05902,�ECM38_YEASTQ8VYW6,�GAGT1_ARATHQ680I5,�GAGT2_ARATH
Q9M0G0,�GAGT3_ARATHD4B387,�GGT1_ARTBCP19440,�GGT1_HUMAN
Q60928,�GGT1_MOUSEP20735,�GGT1_PIGP07314,�GGT1_RAT
Q9US04,�GGT1_SCHPOO14194,�GGT2_SCHPOA6NGU5,�GGT3_HUMAN
P36269,�GGT5_HUMANQ9Z2A9,�GGT5_MOUSEQ9QWE9,�GGT5_RAT
A7YWM1,�GGT6_BOVINQ6P531,�GGT6_HUMANQ6PDE7,�GGT6_MOUSE
Q6IE08,�GGT6_RATQ0V8L2,�GGT7_BOVINQ9UJ14,�GGT7_HUMAN
Q99JP7,�GGT7_MOUSEQ99MZ4,�GGT7_RATP63186,�GGT_BACNA
P54422,�GGT_BACSUP18956,�GGT_ECOLIQ9I406,�GGT_PSEAE
P36267,�GGT_PSEUAP74181,�GGT_SYNY3P15557,�PAC1_PSES3
Q05053,�PAC1_PSESVB8NM71,�USTH_ASPFNO05218,�YWRD_BACSU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-