Frizzled-7

Frizzled-7 (Fd-7) is a protein that in humans is encoded by the FZD7 gene.

FZD7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Z33
Identifiers
Aliases	FZD7, FzE3, frizzled class receptor 7
External IDs	OMIM: 603410; MGI: 108570; HomoloGene: 20751; GeneCards: FZD7; OMA:FZD7 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q33.1 Start 202,033,855 bp End 202,038,441 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C2|1 30.08 cM Start 59,521,583 bp End 59,526,114 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hair follicle germinal epithelium urethra lactiferous duct tibia parotid gland cerebellar vermis parietal pleura cardiac muscle tissue of right atrium seminal vesicula Top expressed in vestibular membrane of cochlear duct medullary collecting duct renal corpuscle ascending aorta vestibular sensory epithelium Epithelium of choroid plexus aortic valve saccule triceps brachii muscle masseter muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding frizzled binding signal transducer activity Wnt-protein binding protein binding transmembrane signaling receptor activity phosphatidylinositol-4,5-bisphosphate binding G protein-coupled receptor activity Wnt-activated receptor activity Cellular component integral component of membrane membrane plasma membrane recycling endosome membrane endosome endosome membrane Biological process negative regulation of cell-substrate adhesion cellular response to retinoic acid G protein-coupled receptor signaling pathway non-canonical Wnt signaling pathway regulation of transcription, DNA-templated positive regulation of epithelial cell proliferation involved in wound healing T cell differentiation in thymus non-canonical Wnt signaling pathway via JNK cascade negative regulation of ectodermal cell fate specification somatic stem cell division positive regulation of JNK cascade Wnt signaling pathway stem cell population maintenance positive regulation of transcription, DNA-templated multicellular organism development cell surface receptor signaling pathway skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration neuron differentiation canonical Wnt signaling pathway substrate adhesion-dependent cell spreading positive regulation of phosphorylation signal transduction mesenchymal to epithelial transition Wnt signaling pathway, planar cell polarity pathway negative regulation of cardiac muscle cell differentiation regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8324 14369 Ensembl ENSG00000155760 ENSMUSG00000041075 UniProt O75084 Q61090 RefSeq (mRNA) NM_003507 NM_008057 RefSeq (protein) NP_003498 NP_032083 Location (UCSC) Chr 2: 202.03 – 202.04 Mb Chr 1: 59.52 – 59.53 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

Interactions

Fz-7 has been shown to interact with DLG4.

Further reading

• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
• Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714. S2CID 39243103.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yao R, Natsume Y, Noda T (2005). "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap". Oncogene. 23 (36): 6023–30. doi:10.1038/sj.onc.1207817. PMID 15195140.
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Vincan E, Darcy PK, Smyth MJ, et al. (2005). "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth". Differentiation. 73 (4): 142–53. doi:10.1111/j.1432-0436.2005.00015.x. PMID 15901282.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Vincan E, Darcy PK, Farrelly CA, et al. (2007). "Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids". Oncogene. 26 (16): 2340–52. doi:10.1038/sj.onc.1210026. PMID 17016432.
• Struewing IT, Barnett CD, Zhang W, et al. (2007). "Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1". Exp. Cell Res. 313 (16): 3526–41. doi:10.1016/j.yexcr.2007.07.012. PMID 17716656.

External links

• "Frizzled Receptors: FZD₇". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.