TUBA1C

Tubulin alpha-1C chain is a protein that in humans is encoded by the TUBA1C gene.

TUBA1C
Identifiers
Aliases	TUBA1C, TUBA6, bcm948, tubulin alpha 1c
External IDs	MGI: 1095409; HomoloGene: 69045; GeneCards: TUBA1C; OMA:TUBA1C - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.12 Start 49,188,736 bp End 49,274,600 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 F1 Start 98,927,772 bp End 98,935,991 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Brodmann area 46 spinal ganglia orbitofrontal cortex inferior ganglion of vagus nerve superior vestibular nucleus inferior olivary nucleus pons trigeminal ganglion subthalamic nucleus Top expressed in Paneth cell fetal liver hematopoietic progenitor cell blastocyst fossa gastrula lip condyle endothelial cell of lymphatic vessel granulocyte yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding structural constituent of cytoskeleton protein binding structural molecule activity GTPase activity Cellular component cytoplasm vesicle microtubule cytoskeleton nucleus microtubule cytoskeleton Biological process cytoskeleton-dependent intracellular transport microtubule-based process cell division cytoskeleton organization microtubule cytoskeleton organization mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84790 22146 Ensembl ENSG00000167553 ENSMUSG00000043091 UniProt Q9BQE3 P68373 RefSeq (mRNA) NM_032704 NM_001303114 NM_001303115 NM_001303116 NM_001303117 NM_009448 RefSeq (protein) NP_001290043 NP_001290044 NP_001290045 NP_001290046 NP_116093 NP_033474 Location (UCSC) Chr 12: 49.19 – 49.27 Mb Chr 15: 98.93 – 98.94 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

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• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Watts NR, Sackett DL, Ward RD, et al. (2000). "HIV-1 rev depolymerizes microtubules to form stable bilayered rings". J. Cell Biol. 150 (2): 349–360. doi:10.1083/jcb.150.2.349. PMC 2180222. PMID 10908577.
• Irobi J, Nelis E, Verhoeven K, et al. (2002). "Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3". J. Peripher. Nerv. Syst. 7 (2): 87–95. doi:10.1046/j.1529-8027.2002.02014.x. PMID 12090300. S2CID 8453412.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–6810. doi:10.1093/emboj/cdf683. PMC 139103. PMID 12486001.
• Xu Y, Kulkosky J, Acheampong E, et al. (2004). "HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 7070–7075. Bibcode:2004PNAS..101.7070X. doi:10.1073/pnas.0304859101. PMC 406467. PMID 15103018.
• Campbell GR, Pasquier E, Watkins J, et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197–48204. doi:10.1074/jbc.M406195200. PMID 15331610.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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• Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology. 2: 7. doi:10.1186/1742-4690-2-7. PMC 549042. PMID 15698476.
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• Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–1318. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
• Canani RB, De Marco G, Passariello A, et al. (2006). "Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells". AIDS. 20 (1): 5–10. doi:10.1097/01.aids.0000198088.85572.68. PMID 16327313. S2CID 21499158.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
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