FDU-PB-22

FDU-PB-22
Legal status
Legal status	CA: Schedule II; DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B;
Identifiers
	IUPAC name naphthalen-1-yl 1-[(4-fluorophenyl)methyl]-1H-indole-3-carboxylate;
CAS Number	1883284-94-3;
PubChem CID	119025888;
ChemSpider	29763739;
UNII	85E88884ZQ;
CompTox Dashboard (EPA)	DTXSID901016910 ;
Chemical and physical data
Formula	C26H18FNO2
Molar mass	395.433 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OC1=C(C=CC=C2)C2=CC=C1)C3=CN(CC4=CC=C(F)C=C4)C5=C3C=CC=C5;
	InChI InChI=1S/C26H18FNO2/c27-20-14-12-18(13-15-20)16-28-17-23(22-9-3-4-10-24(22)28)26(29)30-25-11-5-7-19-6-1-2-8-21(19)25/h1-15,17H,16H2; Key:RCEKSVIFQKKFLS-UHFFFAOYSA-N;

FDU-PB-22 is a derivative of JWH-018 that is presumed to be a potent agonist of the CB₁ receptor, and has been sold online as a designer drug.^[1]^[2]

Pharmacology

FDU-PB-22 acts as a full agonist with a binding affinity of 1.19nM at CB₁ and 2.43nM at CB₂ cannabinoid receptors.^[3]

FDU-PB-22 is a controlled substance in Germany and is banned in Japan and Sweden.^[4]

^ "FDU-PB-22". Southern Association of Forensic Scientists. Archived from the original on 27 May 2015. Retrieved 23 July 2015.
^ Uchiyama N, Shimokawa Y, Kikura-Hanajiri R, Demizu Y, Goda Y, Hakamatsuka T (1 July 2015). "N-OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products". Forensic Toxicology. 33 (2): 244–259. doi:10.1007/s11419-015-0268-7. PMC 4525202. PMID 26257833.
^ Hess C, Schoeder CT, Pillaiyar T, Madea B, Müller CE (1 July 2016). "Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice". Forensic Toxicology. 34 (2): 329–343. doi:10.1007/s11419-016-0320-2. PMC 4929166. PMID 27429655.
^ "Cannabinoider föreslås bli klassificerade som hälsofarlig vara". Folkhälsomyndigheten. 28 May 2014. Retrieved 23 July 2015.

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Legal status

Legal status	CA: Schedule II DE: Anlage II (Authorized trade only, not prescriptible) UK: Class B
Identifiers
IUPAC name naphthalen-1-yl 1-[(4-fluorophenyl)methyl]-1H-indole-3-carboxylate
CAS Number	1883284-94-3
PubChem CID	119025888
ChemSpider	29763739
UNII	85E88884ZQ
CompTox Dashboard (EPA)	DTXSID901016910
Chemical and physical data
Formula	C₂₆H₁₈FNO₂
Molar mass	395.433 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(OC1=C(C=CC=C2)C2=CC=C1)C3=CN(CC4=CC=C(F)C=C4)C5=C3C=CC=C5
InChI InChI=1S/C26H18FNO2/c27-20-14-12-18(13-15-20)16-28-17-23(22-9-3-4-10-24(22)28)26(29)30-25-11-5-7-19-6-1-2-8-21(19)25/h1-15,17H,16H2 Key:RCEKSVIFQKKFLS-UHFFFAOYSA-N