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Fungus-growing ants use antibiotic-producing bacteria to control garden parasites

Nature volume 398, pages 701–704 (1999)Cite this article

A Corrigendum to this article was published on 22 May 2003

Abstract

The well-studied, ancient and highly evolved mutualism between fungus-growing ants and their fungi has become a model system in the study of symbiosis1,5. Although it is thought at present to involve only two symbionts, associated with each other in near isolation from other organisms1,5, the fungal gardens of attine ants are in fact host to a specialized and virulent parasitic fungus of the genus Escovopsis (Ascomycotina)6. Because the ants and their fungi are mutually dependent, the maintenance of stable fungal monocultures in the presence of weeds or parasites is critical to the survival of both organisms. Here we describe a new, third mutualist in this symbiosis, a filamentous bacterium (actinomycete) of the genus Streptomyces that produces antibiotics specifically targeted to suppress the growth of the specialized garden-parasite Escovopsis. This third mutualist is associated with all species of fungus-growing ants studied, is carried upon regions of the ants' cuticle that are genus specific, is transmitted vertically (from parent to offspring colonies), and has the capacity to promote the growth of the fungal mutualist, indicating that the association of Streptomyces with attine ants is both highly evolved and of ancient origin.

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Figure 1: Photograph showing the presence of the third mutualist, Streptomyces, on the cuticle of Acromyrmex octospinosus.
Figure 2: Scanning electron micrographs of fungus-growing ants, showing thelocation of Streptomyces.
Figure 3

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Acknowledgements

This work was supported by Smithsonian and NSERC predoctoral awards (to C.R.C.) and an NSERC grant (to D.M.). C.R.C. thanks the Smithsonian Tropical Research Institute and ANAM of the Republic of Panama for assisting with the research and granting collecting permits, and U.G. Mueller for guidance, support and encouragement. We thank I. Ahmad, N. Alasti-Faridani, G. de Alba, S.Barrett, E. Bermingham, A. Caballero, J. Ceballo, S. Dalla Rosa, L. Ketch, M. Leone, G. Maggiori, S.Rand and M. Witkowska for logistical support; C. Ziegler for the photograph in Fig. 1; and K. Boomsma, J. Bot, R.Cocroft, G. Currie, J. Gloer, A. Herre, H. Herz, S. Rehner, T. Schultz, N. Straus, B. Wcislo and B. Wong for comments on this study and/or manuscript.

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Authors and Affiliations

  1. Smithsonian Tropical Research Institute, PO Box 2072, Balboa, Republic of Panama

    Cameron R. Currie

  2. Departments of Botany, Toronto, M5S 3B2, Ontario, Canada

    Cameron R. Currie, James A. Scott & David Malloch

  3. Laboratory Medicine and Pathobiology, University of Toronto, Toronto, M5S 3B2, Ontario, Canada

    Richard C. Summerbell

  4. Ontario Ministry of Health, 81 Resources Road, Toronto, M9P 3T1, Ontario, Canada

    Richard C. Summerbell

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  1. Cameron R. Currie
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Correspondence to Cameron R. Currie.

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Currie, C., Scott, J., Summerbell, R. et al. Fungus-growing ants use antibiotic-producing bacteria to control garden parasites. Nature 398, 701–704 (1999). https://doi.org/10.1038/19519

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